Sino Biological/NME1 Protein, Human, Recombinant (His Tag)/1/11615-H07E
商品编号：
11615-H07E
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NME1 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 98 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Kinase activity untested
Protein Construction
A DNA sequence encoding the human NME1 isoform b (NP_000260.1) (Ala 2-Glu 152) was expressed, with a polyhistide tag at the N-terminus.
Accession#
NP_000260.1
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant human NME1 consisting of 158 amino acids and has a calculated molecular mass of 18 kDa. It migrates as an approximately 21 kDa band in SDS-PAGE under reducing conditions.
Formulation
Supplied as sterile PBS, pH 7.4Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NME1 Protein, Human, Recombinant (His Tag): Images
NME1 Protein, Human, Recombinant (His Tag): Synonyms
AWD Protein, Human; GAAD Protein, Human; NB Protein, Human; NBS Protein, Human; NDKA Protein, Human; NDPK-A Protein, Human; NDPKA Protein, Human; NM23 Protein, Human; NM23-H1 Protein, Human
NME1 Background Information
NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in the Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene.
Full Name
NME/NM23 nucleoside diphosphate kinase 1
References
- Allard L, et al. (2005) PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin Chem. 51(11): 2043-51.
- Steeg PS, et al. (2008) Clinical-translational approaches to the Nm23-H1 metastasis suppressor. Clin Cancer Res. 14(16): 5006-12.
- Kim HD, et al. (2009) Regulators affecting the metastasis suppressor activity of Nm23-H1. Mol Cell Biochem. 329(1-2): 167-73.
- A single-cell reference map for human blood and tissue T cell activation reveals functional states in health and diseaseAuthorSzabo, PA;Levitin, HM;Miron, M;Snyder, ME;Senda, T;Year2019JournalbioRxivFoldedExpand
- Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and diseaseAuthorSzabo, PA;Levitin, HM;Miron, M;Snyder, ME;Senda, T;Yuan, J;Cheng, YL;Bush, EC;Dogra, P;Thapa, P;Farber, DL;Sims, PA;Year2019JournalNat CommunApplicationFACPubMed ID: 31624246FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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