Sino-Biological/CD63蛋白，人，重组（ECD，His-Tag）/1/11271-H08H
商品编号：
11271-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD63 Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the second extracellular domain of human CD63 (P08962-1) (Ala 103-Val 203) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
Accession#
P08962-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ala 103
Molecule Mass
The recombinant human CD63 consists of 112 amino acids after removal of the signal peptide and has a predicted molecular mass of 13 kDa. The apparent molecular mass of rh CD63 is approximately 22.8 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD63 Protein, Human, Recombinant (ECD, His Tag): Images
CD63 Protein, Human, Recombinant (ECD, His Tag): Synonyms
LAMP-3 Protein, Human; ME491 Protein, Human; MLA1 Protein, Human; OMA81H Protein, Human; TSPAN30 Protein, Human
CD63 Background Information
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 63 (CD63) is a member of the CD family and the transmembrane 4 superfamily, also known as the tetraspanin family. CD63 is a cell surface glycoprotein characterized by the presence of four hydrophobic domains. CD63 had functions in mediating signal transduction processes and then regulate a variety of cellular processes such as cell proliferation, activation and motility. It has been reported that CD63 protein associated with tumor progression and served as a blood platelet activation marker and the deficiency of this protein may be associated with Hermansky-Pudlak syndrome.
Full Name
CD63 molecule
References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Radford KJ, et al. (1996) Associates with Transmembrane 4 Superfamily Members, CD9 and CD81, and with beta 1 Integrins in Human Melanoma. Biochemical Biophysical Research Communications. 222(1): 13-18.
- Metzelaar MJ, et al. (1991) CD63 antigen, A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. The journal of biological chemistry. 266: 3239-45.
Mouse CD63 Proteins
- CD63 Protein, Mouse, Recombinant50557-MNAH
- CD63 Protein, Mouse, Recombinant50557-MNCH
- CD63 Protein, Mouse, Recombinant (ECD, hFc Tag)50557-M01H
Rat CD63 Proteins
- CD63 Protein, Rat, Recombinant (His Tag)80304-R07H
- CD63 Protein, Rat, Recombinant (mFc Tag)80304-R04H
Cynomolgus CD63 Proteins
- CD63 Protein, Cynomolgus, Recombinant (His Tag)90191-C08H
Sus scrofa (Pig) CD63 Proteins
- CD63 Protein, Sus scrofa (Pig), Recombinant (hFc Tag)13657-W02H
- Host protein CD63 enhances viral RNA replication by interacting with human astrovirus nonstructural protein nsP1a/4Authorzhao, w;liu, N;Tao, X;Zheng, C;Li, X;Yu, M;Li, Y;Year2018JournalbioRxivApplicationbindingFoldedExpand
- Aptamer-based fluorescence polarization assay for separation-free exosome quantificationAuthorZhang, Z;Tang, C;Zhao, L;Xu, L;Zhou, W;Dong, Z;Yang, Y;Xie, Q;Fang, X;Year2019JournalNanoscaleApplicationbinding (aptamer)PubMed ID: 31089660FoldedExpand
- A novel aptamer LL4A specifically targets Vemurafenib-resistant melanoma through binding to the CD63 proteinAuthorLi, H;Liu, J;Xiao, X;Sun, S;Zhang, H;Zhang, Y;Zhou, W;Zhang, B;Roy, M;Liu, H;Ye, M;Wang, Z;Liu-Smith, F;Liu, J;Year2019JournalMolecular Therapy - Nucleic AcidsApplicationbinding (aptamer)FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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