Sino Biological/Interferon Gamma Protein, Human, Recombinant/1/11725-HNAS
商品编号：
11725-HNAS
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Interferon Gamma Protein, Human, Recombinant: Product Information
Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC50 for this effect is typically 0.1-0.5 ng/mL.
Protein Construction
A DNA sequence encoding the human γ-IFN (NP_000610.2) (Met 1-Gln 166) was expressed and purified.
Accession#
NP_000610.2
Expressed Host
CHO Stable Cells
Species
Human
Predicted N Terminal
Gln 24
Molecule Mass
The secreted recombinant human γ-IFN consists of 143 amino acids and has a predicted molecular mass of 16.7 kDa. γ-IFN migrates as two bands with apparent molecular mass of 21&25 kDa probably due to different glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Interferon Gamma Protein, Human, Recombinant: Images
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC50 for this effect is typically 0.1-0.5 ng/mL.
Interferon Gamma Protein, Human, Recombinant: Synonyms
IFG Protein, Human; IFI Protein, Human; IFN gamma Protein, Human; Interferon Gamma Protein, Human
Interferon Gamma Background Information
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and tumor control. Aberrant IFN gamma expression is associated with some autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interferon, gamma
Research Areas
- Neuroinflammation
Related Pathways
IL12 signaling pathway
References
- Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
- Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
- Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
- Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
- Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
- Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.
Human Interferon Gamma Proteins
- Interferon Gamma Protein, Human, RecombinantGMP-11725-HNAS
Mouse Interferon Gamma Proteins
- Interferon Gamma Protein, Mouse, Recombinant (His Tag)50709-M08H
- Interferon Gamma Protein, Mouse, Recombinant (hFc Tag)50709-M02H
- Interferon Gamma Protein, Mouse, Recombinant50709-MNAH
Rat Interferon Gamma Proteins
- Interferon Gamma Protein, Rat, Recombinant (hFc Tag)80234-R02H
Ferret Interferon Gamma Proteins
- Interferon Gamma Protein, Ferret, Recombinant (His Tag)60007-F08H
Rhesus Interferon Gamma Proteins
- Interferon Gamma Protein, Rhesus, Recombinant (His Tag)90008-C08H
- Interferon Gamma Protein, Rhesus, Recombinant90008-CNAE
- Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clusteringAuthorWei, M;Fan, X;Ding, M;Li, R;Shao, S;Hou, Y;Meng, S;Year2019JournalbioRxivApplicationcell-basedPubMed ID: 31214999FoldedExpand
- CD137 ligand feedback upregulates PD-L1 expression on lung cancer via T cell production of IFN-γAuthorWang, H;Yan, Z;Hao, J;Yang, B;Wang, J;Yi, L;Wang, X;Li, S;Zhang, H;Zhang, S;Year2019JournalThorac CancerApplicationcell-basedPubMed ID: 31625289FoldedExpand
- A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2AuthorXu, Y;Wu, Y;Zhang, S;Ma, P;Jin, X;Wang, Z;Yao, M;Zhang, E;Tao, B;Qin, Y;Chen, H;Liu, A;Chen, M;Xiao, M;Lu, C;Mao, R;Fan, Y;Year2019JournalCell RepApplicationcell-basedPubMed ID: 31825827FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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