Sino Biological/Clusterin Protein, Human, Recombinant (His Tag)/1/11297-H08H
商品编号：
11297-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Clusterin Protein, Human, Recombinant (His Tag): Product Information
Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human CLU isoform long (NP_001822.2) (Met 1-Glu 501) was expressed, with a C-terminal polyhistidine tag.
Accession#
NP_001822.2
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Asp 75 (β chain ) & Ser 280 (α chain)
Molecule Mass
The full length of recombinant human CLU comprises 438 amino acids and has a calculated molecular mass of 51.5 kDa (24.5 + 27). The apparent molecular mass of the recombinant protein is approximately 37-39 kDa in SDS-PAGE under reducing conditions, corresponding to the cleaved β chain, and α chain respectively.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Clusterin Protein, Human, Recombinant (His Tag): Images
Clusterin Protein, Human, Recombinant (His Tag): Synonyms
AAG4 Protein, Human; APO-J Protein, Human; APOJ Protein, Human; CLI Protein, Human; CLU1 Protein, Human; CLU2 Protein, Human; KUB1 Protein, Human; NA1/NA2 Protein, Human; SGP-2 Protein, Human; SGP2 Protein, Human; SP-40 Protein, Human; TRPM-2 Protein, Human; TRPM2 Protein, Human
Clusterin Background Information
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer"s disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
Full Name
clusterin
References
- Silkensen JR, et al. (1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12): 483-8.
- Naik RR, et al. (2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72.
- Djeu JY, et al. (2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.
Mouse Clusterin Proteins
- Clusterin Protein, Mouse, Recombinant (His Tag)50485-M08H
- Intraventricular apolipoprotein ApoJ infusion acts protectively in Traumatic Brain InjuryAuthorHuang, Z;Cheng, C;Jiang, L;Yu, Z;Cao, F;Zhong, J;Guo, Z;Sun, X;Year2016JournalJ. Neurochem.Applicationanimal-basedPubMed ID: 26670094FoldedExpand
- Colorimetric Paper-Based Immunosensor for Simultaneous Determination of Fetuin B and Clusterin toward Early Alzheimer"s DiagnosisAuthorBrazaca, LC;Moreto, JR;Martín, A;Tehrani, F;Wang, J;Zucolotto, V;Year2019JournalACS NanoPubMed ID: 31661258FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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