Sino Biological/FSTL1 Protein, Human, Recombinant (His Tag)/1/10924-H08H
商品编号：
10924-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
FSTL1 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 98 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human FSTL1 (NP_009016.1) precursor (Met 1-Ile 308) with a carboxy-terminal polyhistidine tag was expressed.
Accession#
NP_009016.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu 21
Molecule Mass
The secreted recombinant human FSTL1 consists of 299 amino acids with the predicted molecular mass of 34.2 kDa. As a result of glycosylation, rhFSTL1 migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FSTL1 Protein, Human, Recombinant (His Tag): Images
FSTL1 Protein, Human, Recombinant (His Tag): Synonyms
FRP Protein, Human; FSL1 Protein, Human; MIR198 Protein, Human
FSTL1 Background Information
Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.
Full Name
follistatin-like 1
References
- Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
- Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
- Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
Mouse FSTL1 Proteins
- FSTL1 Protein, Mouse, Recombinant (His Tag)51127-M08H
- FSTL1 Protein, Mouse, Recombinant (hFc Tag)51127-M02H
Rat FSTL1 Proteins
- FSTL1 Protein, Rat, Recombinant (His Tag)80885-R08H
- FSTL1 Protein, Rat, Recombinant (His Tag)80885-H08H
- Follistatin-like protein 1 sustains colon cancer cell growth and survivalAuthorBevivino, G;Sedda, S;Franzè, E;Stolfi, C;Di Grazia, A;Dinallo, V;Caprioli, F;Facciotti, F;Colantoni, A;Ortenzi, A;Rossi, P;Monteleone, G;Year2018JournalOncotargetApplicationcell-basedPubMed ID: 30131854FoldedExpand
- Follistatin-like protein 1 inhibits lung cancer metastasis by preventing proteolytic activation of osteopontinAuthorChiou, J;Chang, YC;Tsai, HF;Lin, YF;Huang, MS;Yang, CJ;Hsiao, M;Year2019JournalCancer Res.Applicationcell-basedPubMed ID: 31653686FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
E.coli protein expression service
Mammalian transient protein expression service
Baculovirus-insect expression service
Stable cell line development service (CHO / HEK293)
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
