汉诺生物/TREM-2蛋白，人，重组（ECD，His-Tag）/1/11084-H08H
商品编号：
11084-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TREM-2 Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met1-Ser174) was expressed fused with a polyhistidine tag at the C-terminus.
Accession#
NP_061838.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
His 19
Molecule Mass
The secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TREM-2 Protein, Human, Recombinant (ECD, His Tag): Images
TREM-2 Protein, Human, Recombinant (ECD, His Tag): Synonyms
TREM-2 Protein, Human; Trem2a Protein, Human; Trem2b Protein, Human; Trem2c Protein, Human
TREM-2 Background Information
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
Full Name
triggering receptor expressed on myeloid cells 2
References
- Bouchon,A. et al., 2000, J. Immunol. 164: 4991-4995.
- Paloneva,J. et al., 2002, Am. J. Hum. Genet. 71:656-662.
- Prada,I. et al., 2006, Neuroscience. 140(4): 1139-48.
- Neumann,H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
- Thrash,JC. et al., 2009, Neurochem Res. 34(1): 38-45.
Mouse TREM-2 Proteins
- TREM-2 Protein, Mouse, Recombinant (hFc Tag)50149-M02H
- TREM-2 Protein, Mouse, Recombinant (His Tag)50149-M08H
- Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgAAuthorNakanishi, K;Morikane, S;Ichikawa, S;Kurohane, K;Niwa, Y;Akimoto, Y;Matsubara, S;Kawakami, H;Kobayashi, H;Imai, Y;Year2017JournalSci RepApplicationbindingPubMed ID: 28368034FoldedExpand
- The Alzheimer"s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathwayAuthorJendresen, C;Årskog, V;Daws, MR;Nilsson, LN;Year2017JournalJ NeuroinflammationApplicationbindingPubMed ID: 28320424FoldedExpand
- Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupAuthorWoollacott, IOC;Nicholas, JM;Heslegrave, A;Heller, C;Foiani, MS;Dick, KM;Russell, LL;Paterson, RW;Keshavan, A;Fox, NC;Warren, JD;Schott, JM;Zetterberg, H;Rohrer, JD;Year2018JournalAlzheimers Res TherApplicationELISA (standard)PubMed ID: 30111356FoldedExpand
- Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegenerationAuthorAlosco, ML;Tripodis, Y;Fritts, NG;Heslegrave, A;Baugh, CM;Conneely, S;Mariani, M;Martin, BM;Frank, S;Mez, J;Stein, TD;Cantu, RC;McKee, AC;Shaw, LM;Trojanowski, JQ;Blennow, K;Zetterberg, H;Stern, RA;Year2018JournalAlzheimers DementApplicationstandardPubMed ID: 30049650FoldedExpand
- The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease riskAuthorDeming, Y;Filipello, F;Cignarella, F;Hsu, S;Mikesell, R;Li, Z;Del-Aguila, J;Dube, U;Farias, F;Bradley, J;Cantoni, C;Benitez, B;Budde, J;Ibanez, L;Fernandez, M;et al.Year2018JournalbioRxivApplicationELISA (standard)PubMed ID: 29789534FoldedExpand
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial FunctionAuthorZhao, Y;Wu, X;Li, X;Jiang, LL;Gui, X;Liu, Y;Sun, Y;Zhu, B;Piña-Crespo, JC;Zhang, M;Zhang, N;Chen, X;Bu, G;An, Z;Huang, TY;Xu, H;Year2018JournalNeuronApplicationOctetPubMed ID: 29518356FoldedExpand
- CSF soluble TREM2 as a measure of immune response along the Alzheimer’s disease continuumAuthorRauchmann, B;Schneider-Axmann, T;Alexopoulos, P;Perneczky, R;Year2018JournalNeurobiology of AgingApplicationELISAPubMed ID: 30458365FoldedExpand
- Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriersAuthorAshton, NJ;Suárez-Calvet, M;Heslegrave, A;Hye, A;Razquin, C;Pastor, P;Sanchez-Valle, R;Molinuevo, JL;Visser, PJ;Blennow, K;Hodges, AK;Zetterberg, H;Year2019JournalAlzheimers Res TherApplicationstandardPubMed ID: 31779670FoldedExpand
- Soluble TREM2 and Inflammatory Proteins in Alzheimer"s Disease Cerebrospinal FluidAuthorRauchmann, BS;Sadlon, A;Perneczky, R;, ;Year2020JournalJ. Alzheimers Dis.ApplicationELISAPubMed ID: 31958095FoldedExpand
- Soluble TREM2 is elevated in Parkinson"s disease subgroups with increased CSF tauAuthorWilson, EN;Swarovski, MS;Linortner, P;Shahid, M;Zuckerman, AJ;Wang, Q;Channappa, D;Minhas, PS;Mhatre, SD;Plowey, ED;Quinn, JF;Zabetian, CP;Tian, L;Longo, FM;Cholerton, B;Montine, TJ;Poston, KL;Andreasson, KI;Year2020JournalBrainApplicationstandardPubMed ID: 32065223FoldedExpand
- Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk regionAuthorSchlepckow, K;Monroe, KM;Kleinberger, G;Cantuti-Castelvetri, L;Parhizkar, S;Xia, D;Willem, M;Werner, G;Pettkus, N;Brunner, B;Sülzen, A;Nuscher, B;Hampel, H;Xiang, X;Feederle, R;Tahirovic, S;Park, JI;Prorok, R;Mahon, C;Liang, CC;Shi, J;Kim, DJ;Sabelström, H;Huang, F;Di Paolo, G;Simons, M;Lewcock, JW;Haass, C;Year2020JournalEMBO Mol MedApplicationWBPubMed ID: 32154671FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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