Sino Biological/IL-1 beta Protein, Human, Recombinant (pro form, His Tag)/1/10139-H07E
商品编号：
10139-H07E
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL-1 beta Protein, Human, Recombinant (pro form, His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
1. Measured by its binding ability in a functional ELISA.2. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1. The EC50 of human IL1R1 is 0.198 μg/mL.
Protein Construction
A DNA sequence encoding the pro form of human IL1β (NP_000567.1, with mutation Glu 6 Lys) (Met 1-Ser 269) was fused with a polyhistidine tag at the N-terminus.
Accession#
NP_000567.1
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant pro form of human IL1β consisting of 280 amino acids and has a calculated molecular mass of 32.3 kDa. It migrates as an approximately 34 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL-1 beta Protein, Human, Recombinant (pro form, His Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1. The EC50 of human IL1R1 is 0.198 μg/mL.
IL-1 beta Protein, Human, Recombinant (pro form, His Tag): Synonyms
IL-1 Protein, Human; IL-1 beta Protein, Human; IL-1B Protein, Human; IL1-BETA Protein, Human; IL1F2 Protein, Human
IL-1 beta Background Information
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interleukin 1, beta
Research Areas
- Neuroinflammation
Related Pathways
IL1 signaling pathway
References
- Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
- Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
- Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.
Human IL-1 beta Proteins
- IL-1 beta Protein, Human, RecombinantGMP-10139-HNAE
- IL-1 beta Protein, Human, Recombinant10139-HNAE
Mouse IL-1 beta Proteins
- IL-1 beta Protein, Mouse, Recombinant50101-MNAE
Rat IL-1 beta Proteins
- IL-1 beta Protein, Rat, Recombinant (pro form, His Tag)80023-R07E
- IL-1 beta Protein, Rat, Recombinant (mature form)80023-RNAE
Cynomolgus IL-1 beta Proteins
- IL-1 beta Protein, Cynomolgus, Recombinant90010-CNAE
Rabbit IL-1 beta Proteins
- IL-1 beta Protein, Rabbit, Recombinant65004-TNAE
Feline IL-1 beta Proteins
- IL-1 beta Protein, Feline, Recombinant67002-UNAE
Sus scrofa (Pig) IL-1 beta Proteins
- IL-1 beta Protein, Sus scrofa (Pig), Recombinant62003-WNAE
Canine IL-1 beta Proteins
- IL-1 beta Protein, Canine, Recombinant70018-DNAE
- Intracellular and extracellular regulation of the inflammatory protease caspase-1AuthorOR ShamaaYear2014JournalThesisApplicationsubstrateFoldedExpand
- Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 CleavageAuthorEdye, ME;Brough, D;Allan, SM;Year2015JournalJ. Biol. Chem.ApplicationsubstratePubMed ID: 26324708FoldedExpand
- Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulinAuthorAinscough, JS;Gerberick, GF;Kimber, I;Dearman, RJ;Year2015JournalJ. Biol. Chem.ApplicationbindingFoldedExpand
- Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1AuthorShamaa, OR;Mitra, S;Gavrilin, MA;Wewers, MD;Year2015JournalPLoS ONEApplicationsubstrateFoldedExpand
- Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γAuthorAinscough, JS;Macleod, T;McGonagle, D;Brakefield, R;Baron, JM;Alase, A;Wittmann, M;Stacey, M;Year2017JournalProc. Natl. Acad. Sci. U.S.AApplicationsubstratePubMed ID: 28289191FoldedExpand
- Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human EosinophilsAuthorEsnault, S;Kelly, E;Johnson, S;DeLain, L;Haedt, M;Noll, A;Sandbo, N;Jarjour, N;Year2019JournalMediators of InflammationApplicationsubstratePubMed ID: 30906226FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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