Sino Biological/Transferrin Receptor/TFRC Protein, Human, Recombinant (ECD, His Tag)/1/11020-H07H
商品编号：
11020-H07H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Transferrin Receptor/TFRC Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 85 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 μg/ml (100 μl/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL.
Protein Construction
A DNA sequence encoding the extracellular domain of human TFRC (AAA61153.1) (Cys89-Phe760) was expressed with a polyhistidine tag at the N-terminus.
Accession#
AAA61153.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
His
Molecule Mass
The recombinant human TFRC comprises 689 amino acids and has a predicted molecular mass of 77.4 kDa.
Formulation
Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 5 % Mannitol, 0.02 % tween80, pH 7.5.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Transferrin Receptor/TFRC Protein, Human, Recombinant (ECD, His Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 μg/ml (100 μl/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL.
Transferrin Receptor/TFRC Protein, Human, Recombinant (ECD, His Tag): Synonyms
CD71 Protein, Human; p90 Protein, Human; T9 Protein, Human; TFR Protein, Human; TFR1 Protein, Human; TR Protein, Human; TRFR Protein, Human
Transferrin Receptor/TFRC Background Information
Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3"-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
Full Name
transferrin receptor
References
- Douabin-GicquelV., et al., 2001,Hum. Genet. 109:393-401.
- Ryschich,E.et al., 2004,Eur J Cancer. 40(9):1418-22.
- TosoniD.,et al., 2005, Cell 123:875-888.
- WollscheidB., et al., 2009, Nat. Biotechnol. 27:378-386.
Human Transferrin Receptor/TFRC Proteins
- Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc Tag)11020-H01H
- Transferrin Receptor/TFRC Protein, Human, Recombinant (His Tag), Biotinylated11020-H07H-B
- Transferrin Receptor/TFRC Protein, Human, Recombinant (His Tag), HPLC-verifiedHPLC-11020-H07H
Mouse Transferrin Receptor/TFRC Proteins
- Transferrin Receptor/TFRC Protein, Mouse, Recombinant (ECD, His Tag)50741-M07H
Cynomolgus, Rhesus Transferrin Receptor/TFRC Proteins
- Transferrin Receptor/TFRC Protein, Cynomolgus, Rhesus, Recombinant (His Tag)90253-C07H
- Transferrin serves as a mediator to deliver organometallic ruthenium(II) anticancer complexes into cellsAuthorGuo, W;Zheng, W;Luo, Q;Li, X;Zhao, Y;Xiong, S;Wang, F;Year2013JournalInorg ChemApplicationReceptor AssayPubMed ID: 23586415FoldedExpand
- Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1AuthorFan, K;Zhou, M;Yan, X;Year2017JournalProtein CellApplicationElisaPubMed ID: 28993977FoldedExpand
- Targeted delivery of C/EBPα-saRNA by RNA aptamers shows anti-tumor effects in a mouse model of advanced pancreatic ductal adenocarcinomaAuthorYoon, S;Huang, K;Andrikakou, P;Vasconcelos, D;Swiderski, P;Reebye, V;Sodergren, M;Habib, N;Rossi, J;Year2019JournalMolecular Therapy - Nucleic AcidsApplicationbinding (aptamer)PubMed ID: 31546149FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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