Sino Biological/CD46 Protein, Human, Recombinant (His Tag)/1/12239-H08H
商品编号：
12239-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD46 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human CD46 (EAW93471.1) extracellular domain (Met 1-Asp 328) was fused with a polyhistidine tag at the C-terminus.
Accession#
EAW93471.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Cys 35
Molecule Mass
The recombinant human CD46 consists of 305 amino acids and has a predicted molecular mass of 34 kDa. As a result of glycosylation, the apparent molecular mass of rh CD46 is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD46 Protein, Human, Recombinant (His Tag): Images
CD46 Protein, Human, Recombinant (His Tag): Synonyms
AHUS2 Protein, Human; MCP Protein, Human; MIC10 Protein, Human; TLX Protein, Human; TRA2.10 Protein, Human
CD46 Background Information
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
Full Name
CD46 molecule, complement regulatory protein
Related Pathways
Complement Activation Pathways
References
- Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
- Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
- Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.
- C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cellsAuthorDouradinha, B;McBurney, SP;Soares de Melo, KM;Smith, AP;Krishna, NK;Barratt-Boyes, SM;Evans, JD;Nascimento, EJ;Marques, ET;Year2014JournalVirus Res.PubMed ID: 24246304FoldedExpand
- Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: Immune targets in demyelinating neuropathies?AuthorMiyaji, K;Paul, F;Shahrizaila, N;Umapathi, T;Yuki, N;Year2014JournalJ. Neuroimmunol.ApplicationELISAPubMed ID: 25156074FoldedExpand
- Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeuticAuthorRichter, M;Yumul, R;Saydaminova, K;Wang, H;Gough, M;Baldessari, A;Cattaneo, R;Lee, F;Wang, CH;Jang, H;Astier, A;Gopal, A;Carter, D;Lieber, A;Year2016JournalMol Ther Methods Clin DevApplicationELISA (standard)PubMed ID: 27069950FoldedExpand
- CD46 facilitates entry and dissemination of human cytomegalovirusAuthorStein, KR;Gardner, TJ;Hernandez, RE;Kraus, TA;Duty, JA;Ubarretxena-Belandia, I;Moran, TM;Tortorella, D;Year2019JournalNat CommunPubMed ID: 31221976FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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