Sino Biological/Neuregulin-1 Protein, Human, Recombinant (ECD, His Tag)/1/10658-H08H
商品编号：
10658-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Neuregulin-1 Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE.
Endotoxin
< 1.0="" eu="" per="" μg="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human NRG1 (NP_001153480.1) (Ser20-Lys238) was expressed with a polyhistidine tag at the C-terminus.
Accession#
NP_001153480.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ser 20
Molecule Mass
The recombinant human NRG1 consists 230 amino acids and predicts a molecular mass of 25.3 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Neuregulin-1 Protein, Human, Recombinant (ECD, His Tag): Images
Neuregulin-1 Protein, Human, Recombinant (ECD, His Tag): Synonyms
ARIA Protein, Human; GGF Protein, Human; GGF2 Protein, Human; HGL Protein, Human; HRG Protein, Human; HRG1 Protein, Human; HRGA Protein, Human; MST131 Protein, Human; MSTP131 Protein, Human; NDF Protein, Human; Neuregulin 1 Protein, Human; NRG1-IT2 Protein, Human; SMDF Protein, Human
Neuregulin-1 Background Information
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
Full Name
neuregulin 1
References
- Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
- Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
- Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
Human Neuregulin-1 Proteins
- Neuregulin-1 Protein, Human, Recombinant (hFc Tag)10658-H01H
- NRG1 Alpha Protein, Human, Recombinant (ECD, His Tag)13499-H08H
- NRG1 Alpha Protein, Human, Recombinant (EGF Domain, Fc Tag)13499-H01H
- Neuregulin-1 Protein, Human, Recombinant (ECD), Biotinylated11609-HNCH-B
- NRG1 Beta 1 Protein, Human, Recombinant (ECD, Fc Tag)11609-H04H
- NRG1 Beta 1 Protein, Human, Recombinant (EGF Domain, Fc Tag)11609-H01H
- NRG1 Beta 1 Protein, Human, Recombinant (ECD)11609-HNCH
- NRG1 Alpha Protein, Human, Recombinant (ECD, Fc Tag)13499-H02H
- NRG1 Beta 1 Protein, Human, Recombinant (ECD, Fc Tag)11609-H01H2
Canine Neuregulin-1 Proteins
- Neuregulin-1 Protein, Canine, Recombinant (His Tag)70084-D07H
- Neuregulin-1 Protein, Canine, Recombinant (ECD)70084-DCCH
- Neuregulin-1 Protein, Canine, Recombinant (ECD, His Tag)70084-D08H
- Neuregulin-1 Protein, Canine, Recombinant (EGF Domain, mFc Tag)70084-D04H
- Neuregulin-1 Protein, Canine, Recombinant (ECD, hFc Tag)70084-D02H
- Exogenous neuregulin-1 attenuates STZ-induced diabetic peripheral neuropathic pain in ratsAuthorZhou, F;Xia, Z;Liu, K;Zhou, Q;Year2017JournalActa Cir BrasApplicationanimal-basedPubMed ID: 28225915FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
E.coli protein expression service
Mammalian transient protein expression service
Baculovirus-insect expression service
Stable cell line development service (CHO / HEK293)
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
