Sino Biological/Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His Tag)/1/40011-V07E
商品编号：
40011-V07E
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the influenza A H1N1 Virus (A/Puerto Rico/8/34/Mount Sinai) NS1 protein (C8XP22) (Asp 2-Val 230) was expressed, with a polyhistidine tag at the N-terminus.
Accession#
C8XP22
Expressed Host
E. coli
Species
H1N1
Predicted N Terminal
Met
Molecule Mass
The recombinant influenza A H1N1 Virus (A/Puerto Rico/8/34/Mount Sinai) NS1 protein comprises 240 amino acids and has a predicted molecular mass of 27.2 kDa. It migrates as an approximately 29 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, 5% glycerol, pH 8.0Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His Tag): Images
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His Tag): Synonyms
NS1 Protein, H1N1
Nonstructural protein 1/NS1 Background Information
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast Asia is currently believed to be responsible for the enhanced virulence of the strain. The Non-structural (NS1) protein of influenza A virus is a non-essential virulence factor that has multiple accessory functions during viral infection. The major role ascribed to NS1 has been its inhibition of host immune responses, especially the limitation of both interferon (IFN) production and the antiviral effects of IFN-induced proteins, such as dsRNA-dependent protein kinase R (PKR) and 2"5"-oligoadenylate synthetase (OAS)/RNase L. Non-structural (NS1) protein is a non-structural protein of the influenza A virus, which could only be expressed when cells are infected. The effect of NS1 protein on the host cell is still not clear. Not only could NS1 remarkably affect metabolism, but it could also slow down cell proliferation by blocking the cell cycle. Non-structural (NS1) protein may lead to the development of novel antiviral drugs, and the use of oncolytic influenza A viruses as potential anti-cancer agents.
References
- Enami,M.etal., 1997, Nippon Rinsho. 55(10):2605-9.
- Bergmann,M.etal., 2000,J Virol. 74(13):6203-6.
- Hale,B.G.et al., 2008,J Gen Virol. 89(Pt 10):2359-76.
- Zhao,L.et al., 2008,Sheng Wu Gong Cheng Xue Bao. 24(11):1912-7
- Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell TranscriptomicsAuthorHorns, F;Dekker, CL;Quake, SR;Year2020JournalCell RepFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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