Sino Biological/BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant/1/10426-HNAE
商品编号：
10426-HNAE
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant: Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.5μg/mL.
Protein Construction
A DNA sequence encoding the mature form of human / mouse / rat / rhesus / canine BMP2 (NP_001191.1) (Gln283-Arg396) was expressed with an initial Met. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
Accession#
NP_001191.1
Expressed Host
E. coli
Species
Human, Mouse, Rat, Rhesus, Canine
Predicted N Terminal
Met
Molecule Mass
The recombinant human / mouse / rat / rhesus / canine BMP2 consists of 115 amino acids and has a predicted molecular mass of 13 kDa. it migrates as an approximately 14 & 27 kDa band in SDS-PAGE under reducing conditions, corresponding to the monomer and homodimer.
Formulation
Lyophilized from sterile 3% CAN, .1 % TFAPlease contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant: Images
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.5μg/mL.
BMP-2 Background Information
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
Full Name
bone morphogenetic protein 2
Research Areas
- Early Mesodermal Lineage Markers
References
- Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6.
- Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.
Danio rerio (zebrafish) BMP-2 Proteins
- BMP-2 Protein, Danio rerio (zebrafish), Recombinant63003-ZNAE
Human, Mouse, Rat, Rhesus, Canine BMP-2 Proteins
- BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc Tag)10426-H01H
- Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated ApoproteinAuthorLi, B;Zheng, YB;Li, DD;Zhen, YS;Year2014JournalJ Pharm SciPubMed ID: 24504597FoldedExpand
- Characterization of BMP signaling dependent osteogenesis using a BMP depletable avianized bone marrow stromal cell line (TVA-BMSC)AuthorYadav, PS;Khan, MP;Prashar, P;Duggal, S;Rath, SK;Chattopadhyay, N;Bandyopadhyay, A;Year2016JournalBoneApplicationcell basedPubMed ID: 27424936FoldedExpand
- Heterologous Secretory Expression and Characterization of Dimerized Bone Morphogenetic Protein 2 in Bacillus subtilisAuthorHanif, MU;Gul, R;Hanif, MI;Hashmi, AA;Year2017JournalBioMed Research InternationalApplicationcell-based (induction)PubMed ID: 29333457FoldedExpand
- Small Ubiquitin-Like Modifier Protein 3 Enhances the Solubilization of Human Bone Morphogenetic Protein 2 in E. coliAuthorHanif, MU;Yaseen, A;Gul, R;Mirza, MU;Nawaz, MH;Ahmed, SS;Aziz, S;Chaudhary, S;Khan, AA;Shoaib, M;Year2018JournalAppl. Biochem. Biotechnol.Applicationcell-basedPubMed ID: 29574511FoldedExpand
- OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZAuthorZhang, Z;Du, J;Wang, S;Shao, L;Jin, K;Li, F;Wei, B;Ding, W;Fu, P;van Dam, H;Wang, A;Jin, J;Ding, C;Yang, B;Zheng, M;Feng, XH;Guan, KL;Zhang, L;Year2018JournalMol. CellPubMed ID: 30472188FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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