Sino Biological/CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag)/1/10109-H02H
商品编号：
10109-H02H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD226 His (Cat: 10565-H08H) at 2 μg/mL (100 μl/well) can bind human CD155 hFc (Cat: 10109-H02H), The EC50 of bind human CD155 hFc is 100-800 ng/mL.
Protein Construction
A DNA sequence encoding the extracellular domain (Met1-Asn343) of human CD155 (P15151-1) was expressed with the C-terminal fused Fc region of human IgG1.
Accession#
P15151-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Trp 21
Molecule Mass
The recombinant human CD155/Fc is a disulfide-linked homodimer. The reduced monomer consists of 561 amino acids and predicts a molecular mass of 61.8 kDa. As a result of glycosylation, the rhCD155/Fc monomer migrates as approximately 95-105 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized human CD226 His (Cat: 10565-H08H) at 2 μg/mL (100 μl/well) can bind human CD155 hFc (Cat: 10109-H02H), The EC50 of bind human CD155 hFc is 100-800 ng/mL.
CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag): Synonyms
CD155 Protein, Human; HVED Protein, Human; Necl-5 Protein, Human; NECL5 Protein, Human; PVS Protein, Human; TAGE4 Protein, Human
CD155/PVR Background Information
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
- Cancer Immunotherapy
- Co-inhibitory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: ICC Antibodies
- Immune Checkpoint Detection: IP Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Proteins
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
poliovirus receptor
Research Areas
- Cancer Drug Targets
References
- Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
- Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
- Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
- Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
- Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
Human CD155/PVR Proteins
- CD155/PVR Protein, Human, Recombinant (His & AVI Tag), Biotinylated10109-H27H-B
- CD155/PVR Protein, Human, Recombinant (His Tag), Biotinylated10109-H08H-B
- CD155/PVR Protein, Human, Recombinant (ECD, His Tag)10109-H08H
- CD155/PVR Protein, Human, Recombinant (hFc Tag), Biotinylated10109-H02H-B
- CD155/PVR Protein, Human, Recombinant10109-HNAH
Mouse CD155/PVR Proteins
- CD155/PVR Protein, Mouse, Recombinant (His Tag)HPLC-50259-M08H
- CD155/PVR Protein, Mouse, Recombinant (mFc Tag)50259-M38H
- CD155/PVR Protein, Mouse, Recombinant (His Tag)50259-M08H
- CD155/PVR Protein, Mouse, Recombinant (His & hFc Tag)50259-M03H
- CD155/PVR Protein, Mouse, Recombinant (ECD, hFc & AVI Tag), Biotinylated50259-M41H-B
Rat CD155/PVR Proteins
- CD155/PVR Protein, Rat, Recombinant (His Tag)80007-R08H
Rhesus CD155/PVR Proteins
- CD155/PVR Protein, Rhesus, Recombinant (His Tag)90005-C08H
- CD226 Involves in Immune SynapseAuthorWei, H;Sun, R;Tian, Z;Hou, S;Ge, K;Zheng, X;Year2014JournalJ. Biol. Chem.ApplicationbindingFoldedExpand
- CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular DomainAuthorS Hou, K Ge, X Zheng, H Wei, R Sun, Z TianYear2014JournalJOURNAL OF BIOLOGICAL CHEMISTRYApplicationbindingPubMed ID: 24451371FoldedExpand
- The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functionsAuthorCJ Chan, L Martinet, S Gilfillan…Year2014JournalNature immunologyPubMed ID: 24658051FoldedExpand
- TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasisAuthorWang, FF;Wang, Y;Wang, L;Wang, TS;Bai, YP;Year2018JournalClin. Exp. Dermatol.Applicationcell-basedPubMed ID: 29512851FoldedExpand
- TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In VitroAuthorZhang, C;Wang, Y;Xun, X;Wang, S;Xiang, X;Hu, S;Cheng, Q;Guo, J;Li, Z;Zhu, J;Year2020JournalJ. Immunother.Applicationcell-basedPubMed ID: 32804915FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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