Sino Biological/CD44 Protein, Human, Recombinant (His Tag)/1/12211-H08H
商品编号：
12211-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD44 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the N-terminal fragment (Met 1-Pro 220) of human CD44 (P16070-1) extracellular domain was fused with a polyhistidine tag at the C-terminus.
Accession#
P16070-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Gln 21
Molecule Mass
The recombinant human CD44 consists of 211 amino acids and has a predicted molecular mass of 23.4 kDa. As a result of glycosylation, the apparent molecular mass of rhCD44 is approximately 43-48 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD44 Protein, Human, Recombinant (His Tag): Images
CD44 Protein, Human, Recombinant (His Tag): Synonyms
CDW44 Protein, Human; CSPG8 Protein, Human; ECMR-III Protein, Human; HCELL Protein, Human; HUTCH-I Protein, Human; IN Protein, Human; LHR Protein, Human; MC56 Protein, Human; MDU2 Protein, Human; MDU3 Protein, Human; MIC4 Protein, Human; Pgp1 Protein, Human
CD44 Background Information
CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.
Full Name
CD44 molecule (Indian blood group)
References
- Bajorath J. (2000) Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions. Proteins. 39(2): 103-11.
- Johnson P, et al. (2000) A role for the cell adhesion molecule CD44 and sulfation in leukocyte-endothelial cell adhesion during an inflammatory response? Biochem Pharmacol. 59(5): 455-65.
- Martin TA, et al. (2003) The role of the CD44/ezrin complex in cancer metastasis. Crit Rev Oncol Hematol. 46(2): 165-86.
- Toole BP, et al. (2008) Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat. 11(3): 110-21.
- Johnson P, et al. (2009) CD44 and its role in inflammation and inflammatory diseases. Inflamm Allergy Drug Targets. 8(3): 208-20.
Human CD44 Proteins
- CD44 Protein, Human, Recombinant (hFc Tag)12211-H02H
Mouse CD44 Proteins
- CD44 Protein, Mouse, Recombinant (His Tag)53953-M08H
- Molecular weight impact on the mechanical forces between hyaluronan and its receptorAuthorJiang, L;Liu, G;Liu, H;Han, J;Liu, Z;Ma, H;Year2018JournalCarbohydrate PolymersApplicationbindingPubMed ID: 30007620FoldedExpand
- Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancerAuthorGeng, B;Pan, J;Zhao, T;Ji, J;Zhang, C;Che, Y;Yang, J;Shi, H;Li, J;Zhou, H;Mu, X;Xu, C;Wang, C;Xu, Y;Liu, Z;Wen, H;You, Q;Year2018JournalJ. Exp. Clin. Cancer Res.ApplicationOctetPubMed ID: 30165890FoldedExpand
- LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltrationAuthorDeng, M;Gui, X;Kim, J;Xie, L;Chen, W;Li, Z;He, L;Chen, Y;Chen, H;Luo, W;Lu, Z;Xie, J;Churchill, H;Xu, Y;Zhou, Z;Wu, G;Yu, C;John, S;Hirayasu, K;Nguyen, N;Liu, X;Huang, F;Li, L;Deng, H;Tang, H;Sadek, A;Zhang, L;Huang, T;Zou, Y;Chen, B;Zhu, H;Arase, H;Xia, N;Jiang, Y;Collins, R;You, M;Homsi, J;Unni, N;Lewis, C;Chen, G;Fu, Y;Liao, X;An, Z;Zheng, J;Zhang, N;Zhang, C;Year2018JournalNaturePubMed ID: 30333625FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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