Sino Biological/TIM-1/KIM-1 Protein, Human, Recombinant (hHis & Fc Tag)/1/11051-H16H
商品编号：
11051-H16H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TIM-1/KIM-1 Protein, Human, Recombinant (hHis & Fc Tag): Product Information
Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus.
Accession#
AAC39862.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu
Molecule Mass
The recombinant human KIM1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 515 amino acids and predicts a molecular mass of 57 kDa. As a result of glycosylation, the apparent molecular mass of KIM1/Fc monomer is approximately 120-140 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TIM-1/KIM-1 Protein, Human, Recombinant (hHis & Fc Tag): Images
TIM-1/KIM-1 Protein, Human, Recombinant (hHis & Fc Tag): Synonyms
CD365 Protein, Human; HACVR Protein, Human; HAVCR Protein, Human; HAVCR-1 Protein, Human; KIM-1 Protein, Human; KIM1 Protein, Human; TIM Protein, Human; TIM-1 Protein, Human; TIM1 Protein, Human; TIMD-1 Protein, Human; TIMD1 Protein, Human
TIM-1/KIM-1 Background Information
HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulin mucin 1 (TIM-1), is a type of integral membrane glycoprotein. KIM-1 protein is widely expressed with the highest levels in the kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy, and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Full Name
hepatitis A virus cellular receptor 1
References
- Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
- Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
- Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
Human TIM-1/KIM-1 Proteins
- TIM-1/KIM-1 Protein, Human, Recombinant11051-HNCH
- TIM-1/KIM-1 Protein, Human, Recombinant (aa 1-135, His Tag)11051-H08H1
- TIM-1/KIM-1 Protein, Human, Recombinant (ECD, His Tag)11051-H07H
Mouse TIM-1/KIM-1 Proteins
- TIM-1/KIM-1 Protein, Mouse, Recombinant (His Tag)50321-M07H
- TIM-1/KIM-1 Protein, Mouse, Recombinant (hHis & Fc Tag)50321-M16H
Rat TIM-1/KIM-1 Proteins
- TIM-1/KIM-1 Protein, Rat, Recombinant (His Tag)80003-R07H
- TIM-1/KIM-1 Protein, Rat, Recombinant (hHis & Fc Tag)80003-R16H
Canine TIM-1/KIM-1 Proteins
- TIM-1/KIM-1 Protein, Canine, Recombinant (His Tag)70001-D07H
- TIM-1/KIM-1 Protein, Canine, Recombinant (mFc Tag)70001-D04H
Rhesus TIM-1/KIM-1 Proteins
- TIM-1/KIM-1 Protein, Rhesus, Recombinant90006-CNCH1
- TIM-1/KIM-1 Protein, Rhesus, Recombinant (His Tag)90006-C07H
- TIM-1/KIM-1 Protein, Rhesus, Recombinant (His Tag)90006-C08H
- Accelerated Receptor Shedding Inhibits Kidney Injury Molecule-1 (KIM-1)-mediated EfferocytosisAuthorGandhi, R;Yi, J;Ha, J;Shi, H;Ismail, O;Nathoo, S;Bonventre, JV;Zhang, X;Gunaratnam, L;Year2014JournalAm. J. Physiol. Renal Physiol.Applicationcell-basedPubMed ID: 24829508FoldedExpand
- Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.AuthorYao, Z;Li, X;Chen, J;Qiao, Y;Shen, F;Shi, B;Liu, J;Ding, J;Peng, L;Li, J;Yuan, Z;Year2018JournalbioRxivApplicationcell-basedFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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