Sino Biological/HE4 Protein, Human, Recombinant (His Tag)/1/12609-H08H
商品编号：
12609-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
HE4 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human WFDC2 (NP_006094.3) (Met 1-Phe 124) was expressed, with a C-terminal polyhistidine tag.
Accession#
NP_006094.3
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu 31
Molecule Mass
The secreted recombinant human WFDC2 comprises 105 amino acids with a predicted molecular mass of 11.3 kDa. It migrates as an approximately 20 and 23-27 KDa band in SDS-PAGE under reducing conditions due to different glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
HE4 Protein, Human, Recombinant (His Tag): Images
HE4 Protein, Human, Recombinant (His Tag): Synonyms
dJ461P17.6 Protein, Human; EDDM4 Protein, Human; HE4 Protein, Human; WAP5 Protein, Human
HE4 Background Information
WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.
Full Name
WAP four-disulfide core domain 2
Research Areas
- Serine Proteases and Regulators
References
- Bingle,L.et al., 2002,Oncogene. 21(17):2768-73.
- Hellström,I.et al., 2003, Cancer Res. 63(13):3695-700.
- Bingle,L.et al., 2006, Respir Res. 7: 61.
- Galgano,M.T.et al., 2006,Mod Pathol.19(6):847-53.
- Sharp,J.A.et al., 2007, Evol Dev. 9(4): 378-92.
Mouse HE4 Proteins
- HE4 Protein, Mouse, Recombinant (His Tag)50715-M08H
Canine HE4 Proteins
- HE4 Protein, Canine, Recombinant (hFc Tag)70012-D02H
- Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosisAuthorLeBleu, VS;Teng, Y;O"Connell, JT;Charytan, D;Müller, GA;Müller, CA;Sugimoto, H;Kalluri, R;Year2013JournalNat. Med.PubMed ID: 23353556FoldedExpand
- Electrochemical quantum dots-based magneto-immunoassay for detection of HE4 protein on metal film-modified screen-printed carbon electrodesAuthorCadkova, M;Kovarova, A;Dvorakova, V;Metelka, R;Bilkova, Z;Korecka, L;Year2018JournalTalantaPubMed ID: 29501129FoldedExpand
- Measuring serum human epididymis secretory protein autoantibody as an early biomarker of lung cancerAuthorYang, B;Ren, N;Guo, B;Xin, H;Yin, Y;Year2020JournalTransl Cancer Res TCRApplicationELISAFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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