Sino Biological/IGF1 Protein, Human, Recombinant/1/10598-HNAY
商品编号：
10598-HNAY
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IGF1 Protein, Human, Recombinant: Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is 15-60ng/mL.
Protein Construction
A DNA sequence encoding the human IGF1 (NP_001104754.1) (Gly49-Ala118) was expressed.
Accession#
P05019-1
Expressed Host
Yeast
Species
Human
Predicted N Terminal
Gly 49
Molecule Mass
The recombinant human IGF1 consists 70 amino acids and predicts a molecular mass of 7.7 kDa.
Formulation
Lyophilized from sterile PBS,pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IGF1 Protein, Human, Recombinant: Images
Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is 15-60ng/mL.
IGF1 Protein, Human, Recombinant: Synonyms
IGF-1 Protein, Human; IGF-I Protein, Human; IGF1A Protein, Human; IGFI Protein, Human; IGF‑I Protein, Human; MGF Protein, Human
IGF1 Background Information
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.
Full Name
insulin-like growth factor 1 (somatomedin C)
Research Areas
- Serine Proteases and Regulators
References
- Jansen M., et al.,(1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611.
- de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184.
- le Bouc Y., et al.,(1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.
Human IGF1 Proteins
- IGF1 LR3 Protein, Human, Recombinant10598-HNAY1
- IGF1 Protein, Human, Recombinant10598-HNAE
Mouse IGF1 Proteins
- IGF1 Protein, Mouse, Recombinant50437-MNAY
- Locally Produced IGF-1 Promotes Hypertrophy of the Ligamentum Flavum via the mTORC1 Signaling PathwayAuthorYan, B;Huang, M;Zeng, C;Yao, N;Zhang, J;Yan, B;Jiang, H;Tian, X;Ao, X;Zhao, H;Zhou, W;Chu, J;Wang, L;Xian, CJ;Zhang, Z;Wang, L;Year2018JournalCell. Physiol. Biochem.Applicationcell-basedPubMed ID: 30016763FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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