Sino Biological/SEMA3A Protein, Human, Recombinant (hFc Tag)/1/10758-H01H
商品编号：
10758-H01H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
SEMA3A Protein, Human, Recombinant (hFc Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE.
Endotoxin
< 1.0="" eu="" per="" μg="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human SEMA3A (NP_006071.1) (Lys26-Phe546) was expressed with the Fc region of human IgG1 at the N-terminus.
Accession#
NP_006071.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu
Molecule Mass
The recombinant human SEMA3A consists 781 amino acids and predicts a molecular mass of 87.7 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SEMA3A Protein, Human, Recombinant (hFc Tag): Images
SEMA3A Protein, Human, Recombinant (hFc Tag): Synonyms
coll-1 Protein, Human; COLL1 Protein, Human; HH16 Protein, Human; Hsema-I Protein, Human; Hsema-III Protein, Human; SEMA1 Protein, Human; SEMAD Protein, Human; SEMAIII Protein, Human; SEMAL Protein, Human; Semaphorin 3A Protein, Human; SemD Protein, Human
SEMA3A Background Information
Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer"s disease
Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
References
- Giordano,A. et al., 2003, J Neurocytol.32(4):345-352.
- Good, P. F. et al., 2005, J. Neurochem.91(3): 716-736.
- Gu, C. et al., 2005, Science.307(5707): 265–268.
- Chadborn,N.H. et al., 2006, J Cell Sci.119(Pt 5):951-957.
- Schmidt,E.F. et al., 2007, Adv Exp Med Biol.600:1-11.
Mouse SEMA3A Proteins
- SEMA3A Protein, Mouse, Recombinant (His Tag)50631-M07H
- SEMA3A Protein, Mouse, Recombinant (hFc Tag)50631-M01H
- Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in developmentAuthorZhang, M;Zhou, Q;Luo, Y;Nguyen, T;Rosenblatt, MI;Guaiquil, VH;Year2018JournalPLoS ONEPubMed ID: 29370308FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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