Sino Biological/NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST Tag)/1/12054-H09E
商品编号：
12054-H09E
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST Tag): Product Information
Purity
> 70 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human RELA (Q04206-1) RHD domian (Met 1-Tyr 306) was fused with the GST tag at the N-terminus.
Accession#
Q04206-1
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant human RELA/GST chimera consists of 540 amino acids and has a predicted molecular mass of 62 kDa. It migrates as an approxiamtely 58 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile 20mM Tris, 0.15M NaCl, 20mM GST, pH 8.0Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST Tag): Images
NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST Tag): Synonyms
NFKB3 Protein, Human; p65 Protein, Human
NF-kB p65 Background Information
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
Full Name
v-rel avian reticuloendotheliosis viral oncogene homolog A
Research Areas
- Apoptosis Transcription Factors and Regulators
Related Pathways
Death Receptor Signaling
EGFR Signaling Pathway
NF-kB (NFkB) Pathway
TNF Signaling
B Cell Receptor Signaling Pathway
P38 MAPK Signaling Pathway
T Cell Receptor Signaling Pathway
IL1 signaling pathway
IL17 signaling pathway
References
- Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
- Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
- Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.
- Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription FactorsAuthorStruntz, NB;Harki, DA;Year2016JournalACS Chem. Biol.ApplicationbindingFoldedExpand
- Inhibition of lncRNA MIR31HG Promotes Osteogenic Differentiation of Human Adipose-Derived Stem CellsAuthorJin, C;Jia, L;Huang, Y;Zheng, Y;Du, N;Liu, Y;Zhou, Y;Year2016JournalStem CellsApplicationbinding (RNA)PubMed ID: 27334046FoldedExpand
- NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell deathAuthorHuang, D;Chen, J;Yang, L;Ouyang, Q;Li, J;Lao, L;Zhao, J;Liu, J;Lu, Y;Xing, Y;Chen, F;Su, F;Yao, H;Liu, Q;Su, S;Song, E;Year2018JournalNat. Immunol.Applicationbinding (RNA)FoldedExpand
- Revealing active ingredients, potential targets, and action mechanism of Ermiao fang for treating endometritis based on network pharmacology strategyAuthorZhang, C;Su, T;Yu, D;Wang, F;Yue, C;Wang, HQ;Year2020JournalJ EthnopharmacolApplicationSPRPubMed ID: 32505843FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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