Sino Biological/IL13RA2蛋白，人，重组（ECD，His-Tag）/1/10350-H08H
商品编号：
10350-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL13RA2 Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 85 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its ability to inhibit IL13-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.02-0.08 μg/mL.
Protein Construction
A DNA sequence encoding the extracellular domain of human IL13Rα2 (NP_000631.1) (Met1-Leu342) was expressed with the a polyhistidine tag at the C-terminus.
Accession#
NP_000631.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Asp 27
Molecule Mass
The recombinant human IL13Rα2 consists of 325 amino acids and predicts a molecular mass of 38 KDa. As a result of glycosylation, it migrates as an approximately 49.7 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL13RA2 Protein, Human, Recombinant (ECD, His Tag): Images
IL13RA2 Protein, Human, Recombinant (ECD, His Tag): Synonyms
CD213A2 Protein, Human; CT19 Protein, Human; IL-13R Protein, Human; IL13BP Protein, Human
IL13RA2 Background Information
Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High-Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.
Full Name
interleukin 13 receptor, alpha 2
References
- Zhou G, et al.. (2005) Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 79(9): 5272-7.
- Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
- Nair BG, et al.. (2011) Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.
- Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5.
Human IL13RA2 Proteins
- IL13RA2 Protein, Human, Recombinant (His Tag), Biotinylated10350-H08H-B
- IL13RA2 Protein, Human, Recombinant (His & hFc Tag)10350-H03H
Mouse IL13RA2 Proteins
- IL13RA2 Protein, Mouse, Recombinant (ECD, mFc Tag)50061-M38H
- IL13RA2 Protein, Mouse, Recombinant (His Tag)50061-M08H
- IL13RA2 Protein, Mouse, Recombinant (His & hFc Tag)50061-M03H
Rat IL13RA2 Proteins
- IL13RA2 Protein, Rat, Recombinant (His Tag)80204-R08H
- IL13RA2 Protein, Rat, Recombinant (hFc Tag)80204-R02H
Canine IL13RA2 Proteins
- IL13RA2 Protein, Canine, Recombinant (hFc Tag)70079-D02H
- IL13RA2 Protein, Canine, Recombinant (His Tag)70079-D08H
- Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancerAuthorGeng, B;Pan, J;Zhao, T;Ji, J;Zhang, C;Che, Y;Yang, J;Shi, H;Li, J;Zhou, H;Mu, X;Xu, C;Wang, C;Xu, Y;Liu, Z;Wen, H;You, Q;Year2018JournalJ. Exp. Clin. Cancer Res.PubMed ID: 30165890FoldedExpand
- Drug Conjugates for Targeting Eph Receptors in GlioblastomaAuthorSharma, P;Roberts, C;Herpai, D;Fokt, I;Priebe, W;Debinski, W;Year2020JournalPharmaceuticalsFoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
E.coli protein expression service
Mammalian transient protein expression service
Baculovirus-insect expression service
Stable cell line development service (CHO / HEK293)
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
