Sino Biological/BDNF Protein, Mouse / Human / Rat / Cynomolgus / Canine , Recombinant/1/50240-MNAS
商品编号：
50240-MNAS
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
BDNF Protein, Mouse / Human / Rat / Cynomolgus / Canine , Recombinant: Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
1. Measured by its ability to bind biotinylated human TrkB-His (Cat:10047-H08H) in functional ELISA.2. Measured by its ability to bind Human TrkB-Fch (Cat:10047-H03H) in functional ELISA.3. Measured by its ability to bind biotinylated mouse TrkB-His (Cat:50132-M08H) in functional ELISA.
Protein Construction
A DNA sequence encoding the human / mouse / rat / cynomolgus / canine BDNF (P21237) (Met1-Arg249) was expressed and its mature form was purified. The mature form of human, mouse, rat, cynomolgus and canine BDNF sequences are identical.
Accession#
P21237
Expressed Host
CHO Stable Cells
Species
Human, Mouse, Rat, Cynomolgus, Canine
Predicted N Terminal
His 131
Molecule Mass
The recombinant mature form of human / mouse / rat / cynomolgus / canine BDNF consists of119 amino acids and predicts a molecular mass of 13.5 KDa.
Formulation
Lyophilized from sterile PBSPlease contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
BDNF Protein, Mouse / Human / Rat / Cynomolgus / Canine , Recombinant: Images
BDNF Background Information
BDNF is a member of the nerve growth factor family. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Full Name
brain-derived neurotrophic factor
References
- Zigova T, et al. (1998) Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 11(4):234-45.
- Acheson A, et al. (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374(6521):450-3.
- Bekinschtein P, et al. (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci. 105(7):2711-6.
Mouse BDNF Proteins
- BDNF Protein, Mouse, Recombinant (His Tag)50240-M08H
- Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cellsAuthorMuller, Q;Beaudet, MJ;De Serres-Bérard, T;Bellenfant, S;Flacher, V;Berthod, F;Year2018JournalActa BiomaterPubMed ID: 30316025FoldedExpand
- In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivoAuthorStack, E;McMurray, S;McMurray, G;Wade, J;Clark, M;Young, G;Marquette, K;Jain, S;Kelleher, K;Chen, T;Lin, Q;Bloom, L;Lin, L;Finlay, W;Suzuki, R;Cunningham, O;Year2020JournalMAbsApplicationSPRPubMed ID: 32329655FoldedExpand
- Therapeutic potential of a TrkB agonistic antibody for Alzheimer"s diseaseAuthorWang, S;Yao, H;Xu, Y;Hao, R;Zhang, W;Liu, H;Huang, Y;Guo, W;Lu, B;Year2020JournalTheranosticsApplicationcell culturePubMed ID: 32550908FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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