Sino Biological/Transthyretin Protein, Human, Recombinant (His Tag)/1/12091-H08H
商品编号：
12091-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Transthyretin Protein, Human, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its binding ability in a functional ELISA.Immobilized recombinant human TTR-His (Cat:12091-H08H）at 10 μg/ml (100 μl/well) can bind recombinant Canine RBP4-Fc (Cat:70006-D02H) with a linear range of 0.3-10.0 μg/ml.
Protein Construction
A DNA sequence encoding the human TTR (NP_000362.1) (Met 1-Glu 147) with a C-terminal polyhistidine tag was expressed.
Accession#
NP_000362.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Gly 21
Molecule Mass
The secreted recombinant human TTR comprises 138 amino acids with a predicted molecular mass of 15.2 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Transthyretin Protein, Human, Recombinant (His Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized recombinant human TTR-His (Cat: 12091-H08H）at 10 μg/ml (100 μl/well) can bind recombinant Canine RBP4-Fc (Cat: 70006-D02H) with a linear range of 0.3-10.0 μg/ml.
Transthyretin Protein, Human, Recombinant (His Tag): Synonyms
CTS Protein, Human; CTS1 Protein, Human; HEL111 Protein, Human; HsT2651 Protein, Human; PALB Protein, Human; TBPA Protein, Human
Transthyretin Background Information
Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein that belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Full Name
transthyretin
References
- Westermark P, et al. (1990) Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc Natl Acad Sci U S A. 87(7): 2843-5.
- Colon W, et al. (1992) Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31(36): 8654-60.
- Hammarstrm P, et al. (2003) Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science. 299(5607): 713-6.
Human Transthyretin Proteins
- Transthyretin Protein, Human, Recombinant (His Tag)12091-H07H
Mouse Transthyretin Proteins
- Transthyretin Protein, Mouse, Recombinant (His Tag)50958-M08H
- LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltrationAuthorDeng, M;Gui, X;Kim, J;Xie, L;Chen, W;Li, Z;He, L;Chen, Y;Chen, H;Luo, W;Lu, Z;Xie, J;Churchill, H;Xu, Y;Zhou, Z;Wu, G;Yu, C;John, S;Hirayasu, K;Nguyen, N;Liu, X;Huang, F;Li, L;Deng, H;Tang, H;Sadek, A;Zhang, L;Huang, T;Zou, Y;Chen, B;Zhu, H;Arase, H;Xia, N;Jiang, Y;Collins, R;You, M;Homsi, J;Unni, N;Lewis, C;Chen, G;Fu, Y;Liao, X;An, Z;Zheng, J;Zhang, N;Zhang, C;Year2018JournalNaturePubMed ID: 30333625FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
E.coli protein expression service
Mammalian transient protein expression service
Baculovirus-insect expression service
Stable cell line development service (CHO / HEK293)
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
