Sino Biological/PDGFRA Protein, Human, Recombinant (His Tag)/1/10556-H08H
商品编号：
10556-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PDGFRA Protein, Human, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its ability to bind human PDGFC-Fc in functional ELISA.
Protein Construction
A DNA sequence encoding the extracellular domain (Met 1-Glu 524) of human PDGFRα (NP_006197.1) was fused with a polyhistidine tag at the C-terminus.
Accession#
NP_006197.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Gln 24
Molecule Mass
The recombinant human PDGFRα consists of 512 amino acids and predicts a molecular mass of 57.7 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhPDGFRα is approximately 90-100 kDa due to the glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
PDGFRA Protein, Human, Recombinant (His Tag): Images
PDGFRA Protein, Human, Recombinant (His Tag): Synonyms
CD140A Protein, Human; PDGFR-2 Protein, Human; PDGFR2 Protein, Human; RHEPDGFRA Protein, Human
PDGFRA Background Information
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
platelet-derived growth factor receptor, alpha polypeptide
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- Oseini AM, et al. (2009) PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma? Expert Opin Ther Targets. 13(4): 443-54.
- Meister M, et al. (2009) Expression and mutational status of PDGFR in thymic tumours. Anticancer Res. 29(10): 4057-61.
- Martinho O, et al. (2009) Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 101(6): 973-82.
Human PDGFRA Proteins
- PDGFRA Protein, Human, Recombinant10556-HCCH
- PDGFRA Protein, Human, Recombinant (hFc Tag)10556-H02H
- PDGFRA Protein, Human, Recombinant (ECD, His & AVI Tag), Biotinylated10556-H27H-B
- PDGFRA Protein, Human, Recombinant (His & GST Tag)10556-H20B1
Mouse PDGFRA Proteins
- PDGFRA Protein, Mouse, Recombinant (ECD, His Tag)57064-M08H
- PDGFRA Protein, Mouse, Recombinant (ECD, hFc Tag)57064-M02H
Rat PDGFRA Proteins
- PDGFRA Protein, Rat, Recombinant (His Tag)80433-R08H
- PDGFRA Protein, Rat, Recombinant (hFc Tag)80433-R02H
- Development of a diagnostic assay for systemic sclerosisAuthorKN PozniakYear2013JournalUNIVERSITÀ POLITECNICA DELLE MARCHE Facoltà di Medicina e ChirurgiaApplicationELISAFoldedExpand
- Epitope specificity determines pathogenicity and detectability of anti-PDGFRα autoantibodies in systemic sclerosisAuthorMoroncini, G;Grieco, A;Nacci, G;Paolini, C;Tonnini, C;Pozniak, KN;Cuccioloni, M;Mozzicafreddo, M;Svegliati, S;Angeletti, M;Kazlauskas, A;Avvedimento, EV;Funaro, A;Gabrielli, A;Year2015JournalArthritis & rheumatologyApplicationImmunoenzymatic assaysPubMed ID: 25808833FoldedExpand
- An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in GlioblastomaAuthorYoon, S;Wu, X;Armstrong, B;Habib, N;Rossi, JJ;Year2018JournalMol Ther Nucleic AcidsApplicationSPR (aptamer)PubMed ID: 30594071FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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