Sino Biological/Galectin-1 Protein, Human, Recombinant/1/10290-HNAE
商品编号：
10290-HNAE
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Galectin-1 Protein, Human, Recombinant: Product Information
Purity
> 98 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 3-30μg/mL.
Protein Construction
A DNA sequence encoding the human Galectin 1 (NP_002296.1) (Met 1-Asp135) was expressed.
Accession#
NP_002296.1
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Ala 2
Molecule Mass
The recombinant human Galectin 1 comprises 134 amino acids without the initiator methonine, and predicts a molecular mass of 15 kDa as estimated in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Galectin-1 Protein, Human, Recombinant: Images
Galectin-1 Protein, Human, Recombinant: Synonyms
GAL1 Protein, Human; Galectin-1 Protein, Human; GBP Protein, Human
Galectin-1 Background Information
Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions.
Full Name
lectin, galactoside-binding, soluble, 1
References
- Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25.
- Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets. 6(4): 375-83.
- Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R.
- Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.
Mouse Galectin-1 Proteins
- Galectin-1 Protein, Mouse, Recombinant50100-MNAE
Rat Galectin-1 Proteins
- Galectin-1 Protein, Rat, Recombinant80248-RNAE
- Prevalence of intracellular galectin-1-expressing lymphocytes in umbilical cord blood in comparison with adult peripheral bloodAuthorKollár, S;Sándor, N;Molvarec, A;Stenczer, B;Rigó, J;Tulassay, T;Vásárhelyi, B;Toldi, G;Year2012JournalBiol. Blood Marrow Transplant.Applicationcell-based (proliferation)PubMed ID: 22609846FoldedExpand
- A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic frameworkAuthorZhang, X;Zeng, Y;Zheng, A;Cai, Z;Huang, A;Zeng, J;Liu, X;Liu, J;Year2017JournalMicrochimica ActaApplicationassay validationFoldedExpand
- Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targeted Therapy in Melanoma CellsAuthorRizzolio, S;Corso, S;Giordano, S;Tamagnone, L;Year2020JournalCancers (Basel)Applicationcell-basedPubMed ID: 32784465FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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