Sino Biological/ErbB4蛋白，人，重组（His&；hFc标签）/1/10363-H03H
商品编号：
10363-H03H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ErbB4 Protein, Human, Recombinant (His & hFc Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
1. Measured by its ability to bind biotinylated human Fc-NRG1 (isoform Beta 1) (Cat:11609-H01H) in a functional ELISA.2. Measured by its ability to bind with biotinylated human NRG1 (isoform Beta 1) (Cat:11609-H01H2) in a functional ELISA.3. Measured by its ability to bind with biotinylated human NRG1 (aa 2-246)-Fc (Cat:11609-H04H) in a functional ELISA.4. Measured by its ability to bind with biotinylated human NRG1 (aa 20-241)-His (Cat:13499-H08H) in a functional ELISA.
Protein Construction
A DNA sequence encoding the extracellular domain (Met 1-Pro 651) of human ErbB4 precursor (NP_001036064.1) was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus.
Accession#
NP_001036064.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu 26
Molecule Mass
The recombinant human ErbB4/Fc is a disulfide-linked homodimeric protein after proteolytic removal of the signal peptide. The reduced monomer consists of 871 amino acids and predicts a molecular mass of 97.5 kDa. As a result of glycosylation, the rh ErbB4/Fc monomer migrates as approximately 125-135 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
ErbB4 Protein, Human, Recombinant (His & hFc Tag): Images
ErbB4 Protein, Human, Recombinant (His & hFc Tag): Synonyms
ALS19 Protein, Human; HER4 Protein, Human; p180erbB4 Protein, Human
ErbB4 Background Information
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
erb-b2 receptor tyrosine kinase 4
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- Huang, Y Z, et al. (2000) Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 26(2):443-55.
- Garcia, R A, et al. (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci. 97(7):3596-601.
- Silberberg G, et al. (2006) The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet. 141(B2):142-8.
- Sardi SP, et al. (2006) Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 127(1):185-97.
Mouse ErbB4 Proteins
- ErbB4 Protein, Mouse, Recombinant (His Tag)51064-M08H
Rat ErbB4 Proteins
- ErbB4 Protein, Rat, Recombinant (His Tag)80125-R08H
- ErbB4 Protein, Rat, Recombinant (hFc Tag)80125-R02H
Human, Rhesus ErbB4 Proteins
- ErbB4 Protein, Human, Rhesus, Recombinant (hFc Tag)10363-H02H
- ErbB4 Protein, Human, Rhesus, Recombinant (His Tag)10363-H08B
- ErbB4 Protein, Human, Rhesus, Recombinant (His Tag)10363-H08H
- Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer"s diseaseAuthorZhang, H;Zhang, L;Zhou, D;He, X;Wang, D;Pan, H;Zhang, X;Mei, Y;Qian, Q;Zheng, T;Jones, FE;Sun, B;Year2017JournalNeurobiol. Dis.ApplicationCo-IPPubMed ID: 28684271FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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