Sino Biological/SR-BI/SCARB1蛋白，人，重组（His标签）/1/11069-H08H
商品编号：
11069-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
SR-BI/SCARB1 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mature form of human SCARB1 (NP_005496.4) extracellular domain (Pro 33-Tyr 443) was fused with a polyhistidine tag at the C-terminus.
Accession#
NP_005496.4
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Pro 33
Molecule Mass
The recombinant human SCARB1 consists of 422 amino acids and has a predicted molecular mass of 48 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSCARB1 is approximately 75-85 kDa due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SR-BI/SCARB1 Protein, Human, Recombinant (His Tag): Images
SR-BI/SCARB1 Protein, Human, Recombinant (His Tag): Synonyms
CD36L1 Protein, Human; CLA-1 Protein, Human; CLA1 Protein, Human; HDLQTL6 Protein, Human; SR-BI Protein, Human; SRB1 Protein, Human
SR-BI/SCARB1 Background Information
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Full Name
scavenger receptor class B, member 1
References
- Murao, K. et al., 1997,J. Biol. Chem.272(28): 17551-17557.
- Ikemoto, M. et al., 2000,Proc. Natl. Acad. Sci. U.S.A.97(12): 6538-6543.
- Husemann, J. et al., 2001, Am. J. Pathol.158(3): 825-832.
- Williams, D.L. et al., 2001,Endocr. Res.26(4): 639-651.
- Bulte, B. S. et al., 2002,J. Biol. Chem.277(39): 36092-36099.
- Duncan, K.G. et al., 2002, Biochem. Biophys. Res. Commun.292(4): 1017-1022.
Human SR-BI/SCARB1 Proteins
- SR-BI/SCARB1 Protein, Human, Recombinant (ECD, hFc Tag)11069-H02H
- SR-BI/SCARB1 Protein, Human, Recombinant (His & hFc Tag)11069-H03H
Mouse SR-BI/SCARB1 Proteins
- SR-BI/SCARB1 Protein, Mouse, Recombinant (His & hFc Tag)50317-M03H
- SR-BI/SCARB1 Protein, Mouse, Recombinant (His Tag)50317-M08H
- All three human scavenger receptor class B proteins can bind and transport all three macular xanthophyll carotenoids.AuthorShyam, R;Vachali, P;Gorusupudi, A;Nelson, K;Bernstein, PS;Year2017JournalArch. Biochem. Biophys.PubMed ID: 28947101FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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