Sino Biological/Cdk5 Protein, Human, Recombinant (GST Tag)/1/10897-H09B
商品编号：
10897-H09B
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Cdk5 Protein, Human, Recombinant (GST Tag): Product Information
Purity
> 94 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
No Kinase Activity
Protein Construction
A DNA sequence encoding the human CDK5 isoform 1 (NP_004926.1) (Met 1-Pro 292) was fused with the GST tag at the N-terminus.
Accession#
NP_004926.1
Expressed Host
Baculovirus-Insect Cells
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant human CDK5/GST chimera consists of 516 amino acids and has a predicted molecular mass of 59.6 kDa as estimated in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, 0.5mM GSH, pH 7.0Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Cdk5 Protein, Human, Recombinant (GST Tag): Images
Cdk5 Protein, Human, Recombinant (GST Tag): Synonyms
PSSALRE Protein, Human
Cdk5 Background Information
Celldivision protein kinase 5, also known as Cyclin-dependent kinase 5,Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalyticsubunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongsto theprotein kinase superfamily, CMGC Ser/Thr protein kinase family andCDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family ofproline-directed Ser/Thr kinases known for their role in the control of cellcycle progression. In 1992, this family was joined by CDK5, which is anatypical member in that it uses its own activators and is multifunctional,playing important regulatory roles in multiple cellular functions. CDK5, unlikeother Cdks, is not regulated by cyclins, and its activity is primarily detectedin postmitotic neurons in developing and adult nervous systems. CDK5 isactivated by association with a neuron-specific activator, p35 or its isoformp39. CDK5 is probably involved in the control of the cell cycle. It interactswith D1 and D3-type G1 cyclins. CDK5 can phosphorylate histone H1, tau, MAP2and NF-H and NF-M. It also interacts with p35 which activates the kinase. CDK5plays important roles in various neuronal activities, including neuronalmigration, synaptic activity, and neuronal cell death.
Full Name
cyclin-dependent kinase 5
References
- Smith,D.S.et al., 2001,Cell Growth Differ.12(6):277-83.
- Mapelli,M.et al., 2003, Neurosignals.12(4-5):164-72.
- Cheng,K.et al., 2003, Neurosignals.12(4-5):180-90.
- Fischer,A.et al., 2003, Curr Drug Targets CNS Neurol Disord 2(6): 375 - 81.
- Lalioti,V.et al., 2010, Cell Cycle9(2): 284-311.
- Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathwayAuthorZhou, X;Gu, R;Han, X;Wu, G;Liu, J;Year2017JournalBiochem. Biophys. Res. Commun.ApplicationreagentPubMed ID: 28842255FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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