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商品详细Sino Biological/TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag)/1/10390-H03H
Sino Biological/TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag)/1/10390-H03H
Sino Biological/TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag)/1/10390-H03H
商品编号: 10390-H03H
品牌: sinobiological
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag): Product Information

Purity
> 88 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human TIMD3 (Q8TDQ0-1) extracellular domain (Met1-Arg200) was fused with the c-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Accession#
Q8TDQ0-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ser 22
Molecule Mass
The recombinant human TIMD3/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 426 amino acids and has a predicted molecular mass of 47.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTIMD3/Fc monomer is approximately 66 kDa due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag): Images

Human TIM-3/HAVCR2Protein 8763

TIM-3 Protein, Human, Recombinant (ECD, His & hFc Tag): Synonyms

CD366 Protein, Human; HAVcr-2 Protein, Human; HAVCR2 Protein, Human; KIM-3 Protein, Human; Tim-3 Protein, Human; TIM3 Protein, Human; TIMD-3 Protein, Human; TIMD3 Protein, Human

TIM-3 Background Information

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.
  • Cancer Immunotherapy
  • Co-inhibitory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: IP Antibodies
  • Immune Checkpoint Detection: WB Antibodies
  • Immune Checkpoint Proteins
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
Full Name
hepatitis A virus cellular receptor 2
Research Areas
  • Cancer Drug Targets
References
  • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
  • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
  • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
  • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.

Human TIM-3 Proteins

  • TIM-3 Protein, Human, Recombinant (mFc Tag), ECD10390-H38H
  • TIM-3 Protein, Human, Recombinant (ECD, His Tag)10390-H08H
  • TIM-3 Protein, Human, Recombinant (ECD, His Tag), Biotinylated10390-H08H-B
  • TIM-3 Protein, Human, Recombinant (ECD, hFc Tag)10390-H02H

Mouse TIM-3 Proteins

  • TIM-3 Protein, Mouse, Recombinant (hFc Tag)51152-M02H
  • TIM-3 Protein, Mouse, Recombinant (ECD, His Tag)51152-M08H

Cynomolgus TIM-3 Proteins

  • TIM-3 Protein, Cynomolgus, Recombinant (hFc Tag)90312-C02H
  • Development of an AlphaLISA Assay for Screening Inhibitors of the TIM-3/Gal-9 Interaction
    Author
    Cao, H;Carlstrom, J;Hopkinton, MA;
    Year
    2017
    Journal
    APPLICATION NOTE
    Application
    AlphaLISA Assays
    FoldedExpand

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品牌介绍
北京义翘神州科技股份有限公司(Sino Biological Inc.)是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司,主要业务包括重组蛋白、抗体、基因和培养基等产品,以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种,其中重组蛋白约 6,000 种,包括超过 3,800 种人源细胞表达重组蛋白产品,能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求;公司还能提供约 12,000 种抗体,其中单克隆抗体数量约 4,600 种,能够覆盖生命科学研究的多个领域,为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司,已成为生物试剂行业国内领先的科技公司之一。