Sino Biological/CD155/PVR蛋白，小鼠，重组（His&；hFc标签）/1/50259-M03H
商品编号：
50259-M03H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD155/PVR Protein, Mouse, Recombinant (His & hFc Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its binding ability in a functional ELISA. Immobilized mouse DNAM1 at 2 μg/ml (100 μl/well) can bind mouse CD155 with a linear range of 6.4-160 ng/ml.
Protein Construction
A DNA sequence encoding the mouse CD155 (NP_081790.1) precursor (Met 1-Arg 345) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Accession#
NP_081790.1
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Gly 28
Molecule Mass
The secreted recombinant mouse CD155/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 566 amino acids with a predicted molecular mass of 63 kDa. As a result of glycosylation, it migrates as an approximately 95-105 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD155/PVR Protein, Mouse, Recombinant (His & hFc Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized mouse DNAM1 at 2 μg/ml (100 μl/well) can bind mouse CD155 with a linear ranger of 6.4-160 ng/ml.
CD155/PVR Protein, Mouse, Recombinant (His & hFc Tag): Synonyms
3830421F03Rik Protein, Mouse; CD155 Protein, Mouse; D7Ertd458e Protein, Mouse; HVED Protein, Mouse; mE4 Protein, Mouse; necl-5 Protein, Mouse; PVS Protein, Mouse; Taa1 Protein, Mouse; Tage4 Protein, Mouse
CD155/PVR Background Information
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
- Cancer Immunotherapy
- Co-inhibitory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: ICC Antibodies
- Immune Checkpoint Detection: IP Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Proteins
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
poliovirus receptor
Research Areas
- Cancer Drug Targets
References
- Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
- Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
- Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
- Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
- Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
Human CD155/PVR Proteins
- CD155/PVR Protein, Human, Recombinant (His & AVI Tag), Biotinylated10109-H27H-B
- CD155/PVR Protein, Human, Recombinant (His Tag), Biotinylated10109-H08H-B
- CD155/PVR Protein, Human, Recombinant (ECD, His Tag)10109-H08H
- CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag)10109-H02H
- CD155/PVR Protein, Human, Recombinant (hFc Tag), Biotinylated10109-H02H-B
- CD155/PVR Protein, Human, Recombinant10109-HNAH
Mouse CD155/PVR Proteins
- CD155/PVR Protein, Mouse, Recombinant (His Tag)HPLC-50259-M08H
- CD155/PVR Protein, Mouse, Recombinant (mFc Tag)50259-M38H
- CD155/PVR Protein, Mouse, Recombinant (His Tag)50259-M08H
- CD155/PVR Protein, Mouse, Recombinant (ECD, hFc & AVI Tag), Biotinylated50259-M41H-B
Rat CD155/PVR Proteins
- CD155/PVR Protein, Rat, Recombinant (His Tag)80007-R08H
Rhesus CD155/PVR Proteins
- CD155/PVR Protein, Rhesus, Recombinant (His Tag)90005-C08H
- HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.AuthorKinosada, H;Yasunaga, JI;Shimura, K;Miyazato, P;Onishi, C;Iyoda, T;Inaba, K;Matsuoka, M;Year2017JournalPLoS PathogApplicationcell-basedPubMed ID: 28046066FoldedExpand
- Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVRAuthorZhou, X;Du, J;Wang, H;Chen, C;Jiao, L;Cheng, X;Zhou, X;Chen, S;Gou, S;Zhao, W;Zhai, W;Chen, J;Gao, Y;Year2020JournalCell Commun. SignalPubMed ID: 32894141FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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