Sino Biological/LRG1蛋白，人，重组/1/13371-HCCH
商品编号：
13371-HCCH
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
LRG1 Protein, Human, Recombinant: Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human LRG1 (AAH34389.1) (Met1-Gln347) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Accession#
AAH34389.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Val 36
Molecule Mass
The recombinant human LRG1 is a disulfide-linked homodimer. The reduced monomer comprises 319 amino acids and has a predicted molecular mass of 35.1 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
LRG1 Protein, Human, Recombinant: Images
LRG1 Protein, Human, Recombinant: Synonyms
HMFT1766 Protein, Human; LRG Protein, Human
LRG1 Background Information
LRG1 (Leucine-Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. LRG1 belongs to the leucine-rich repeat (LRR) family. Members of this family are involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. It contains 4 LIM zinc-binding domains and 1 Rho-GAP domain. LRG1 is involved in promoting neovascularization (new blood vessel growth) by causing a switch in transforming growth factor-beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway. It may be a potential therapeutic target for the treatment of diseases where there is aberrant neovascularization. Diseases associated with LRG1 include Appendicitis and Normal Pressure Hydrocephalus.
Full Name
leucine-rich alpha-2-glycoprotein 1
Research Areas
- Cardiac Stem Cell Markers
References
- O Donnell LC. et al., 2002, J Leukoc Biol. 72 (3): 478-85.
- Li X. et al., 2007, Neurosci Lett. 413 (2): 141-4.
- Ramachandran P. et al., 2006, J Proteome Res. 5 (6): 1493-503.
Human LRG1 Proteins
- LRG1 Protein, Human, Recombinant (His Tag)13371-H08H
- LRG1 Protein, Human, Recombinant (hFc Tag)13371-H02H
- Leucine Rich α-2 Glycoprotein: A Novel Neutrophil Granule Protein and Modulator of MyelopoiesisAuthorDruhan, LJ;Lance, A;Li, S;Price, AE;Emerson, JT;Baxter, SA;Gerber, JM;Avalos, BR;Year2017JournalPLoS ONEApplicationcell-basedPubMed ID: 28081565FoldedExpand
- LRG1 Suppresses Migration and Invasion of Esophageal Squamous Cell Carcinoma by Modulating Epithelial to Mesenchymal TransitionAuthorZhang, N;Ren, Y;Wang, Y;Zhao, L;Wang, B;Ma, N;Gao, Z;Cao, B;Year2020JournalJ CancerApplicationcell-basedPubMed ID: 32047555FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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