Sino Biological/抑制素βA/激活素A蛋白，人，小鼠，大鼠，食蟹猴，恒河猴，重组/1/10429-HNAH
商品编号：
10429-HNAH
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Inhibin beta A/Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant: Product Information
Purity
> 95 % as determined by SDS-PAGE.
Endotoxin
< 1.0="" eu="" per="" μg="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 4-16ng/mL.
Protein Construction
A DNA sequence encoding mature form of human / mouse / rat / cynomolgus / rhesus INHBA (NP_002183.1) (Gly311-Ser426) was expressed. The mature form sequences of the human, mouse, rat, cynomolgus and rhesus INHBA are identical.
Accession#
NP_002183.1
Expressed Host
HEK293 Cells
Species
Human, Mouse, Rat, Cynomolgus, Rhesus
Predicted N Terminal
Gly 311
Molecule Mass
The recombinant human / mouse / rat / cynomolgus / rhesus INHBA consists of116 amino acids and predicts a molecular mass of 13 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Inhibin beta A/Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant: Images
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 4-16ng/mL.
Inhibin beta A/Activin A Background Information
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Also, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in the epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects.
Full Name
inhibin, beta A
Research Areas
- Early Mesodermal Lineage Markers
References
- Tanimoto K, et al. (1992) Structure and sequence analysis of the human activin beta A subunit gene. DNA Seq. 2 (2): 103-10.
- Welt C, et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med. 227 (9): 724-52.
- Xu J, et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 270 (11): 6308-13.
Mouse Inhibin beta A/Activin A Proteins
- Inhibin beta A/Activin A Protein, Mouse, Recombinant (His Tag)50659-M08H
- PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCsAuthorShan, Y;Liang, Z;Xing, Q;Zhang, T;Wang, B;Tian, S;Huang, W;Zhang, Y;Yao, J;Zhu, Y;Huang, K;Liu, Y;Wang, X;Chen, Q;Zhang, J;Shang, B;Li, S;Shi, X;Liao, B;Zhang, C;Lai, K;Zhong, X;Shu, X;Wang, J;Yao, H;Chen, J;Pei, D;Pan, G;Year2017JournalNat CommunApplicationcell-based(culture)PubMed ID: 28939884FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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