华生物/PDGFRB蛋白，人，重组（His-Tag）/1/10514-H08H
商品编号：
10514-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PDGFRB Protein, Human, Recombinant (His Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its binding ability in a functional ELISA. Immobilized PDGFRβ-His at 10 μg/ml (100 μl/well) can bind Cynomolgus PDGFB (Cat:90030-C04H), The EC50 of Cynomolgus PDGFB (Cat:90030-C04H) is 3-8 ng/ml.
Protein Construction
A DNA sequence encoding the human PDGFRβ (NP_002600.1) extracellular domain (Met 1-Lys 531) was expressed, with a C-terminal polyhistidine tag.
Accession#
NP_002600.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Leu 33
Molecule Mass
The secreted recombinant human PDGFRβ comprises 510 amino acids and predicts a molecular mass of 57.6 kDa. It migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
PDGFRB Protein, Human, Recombinant (His Tag): Images
Measured by its binding ability in a functional ELISA. Immobilized PDGFRβ-His at 10 μg/ml (100 μl/well) can bind Cynomolgus PDGFB (Cat: 90030-C04H), The EC50 of Cynomolgus PDGFB (Cat: 90030-C04H) is 3-8 ng/ml.
PDGFRB Protein, Human, Recombinant (His Tag): Synonyms
CD140B Protein, Human; IBGC4 Protein, Human; IMF1 Protein, Human; JTK12 Protein, Human; KOGS Protein, Human; PDGFR Protein, Human; PDGFR-1 Protein, Human; PDGFR1 Protein, Human; PENTT Protein, Human
PDGFRB Background Information
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
platelet-derived growth factor receptor, beta polypeptide
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.
Human PDGFRB Proteins
- PDGFRB Protein, Human, Recombinant10514-HCCH
- PDGFRB Protein, Human, Recombinant (ECD)10514-HNAH
- PDGFRB Protein, Human, Recombinant (His Tag), Biotinylated10514-H08H-B
- PDGFRB Protein, Human, Recombinant (ECD, hFc Tag)10514-H02H1
- PDGFRB Protein, Human, Recombinant (His & hFc Tag)10514-H03H
Rat PDGFRB Proteins
- PDGFRB Protein, Rat, Recombinant (His Tag)80347-R08H
- PDGFRB Protein, Rat, Recombinant (hFc Tag)80347-R02H
Rhesus PDGFRB Proteins
- PDGFRB Protein, Rhesus, Recombinant (His Tag)90215-C08H
- PDGFRB Protein, Rhesus, Recombinant (hFc Tag)90215-C02H
- CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier developmentAuthorChen, J;Luo, Y;Hui, H;Cai, T;Huang, H;Yang, F;Feng, J;Zhang, J;Yan, X;Year2017JournalProc. Natl. Acad. Sci. U.S.A.PubMed ID: 28827364FoldedExpand
- Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cellsAuthorWang, X;Gao, Y;Li, Y;Huang, Y;Zhu, Y;Lv, W;Wang, R;Gou, L;Cheng, C;Feng, Z;Xie, J;Tian, J;Yao, R;Year2020JournalCell Death DisApplicationSPRPubMed ID: 32541811FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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