Sino Biological/IFNAR1 Protein, Human, Recombinant (His Tag)/1/13222-H08H
商品编号：
13222-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IFNAR1 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human IFNAR1 isoform 1 (P17181-1) extracellular domain (Met 1-Lys 436) was fused with a polyhistidine tag at the C-terminus.
Accession#
P17181-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Lys 28
Molecule Mass
The recombinant human IFNAR1 consists of 420 amino acids and has a predicted molecular mass of 48.6 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IFNAR1 Protein, Human, Recombinant (His Tag): Images
IFNAR1 Protein, Human, Recombinant (His Tag): Synonyms
AVP Protein, Human; IFN-alpha-REC Protein, Human; IFNAR Protein, Human; IFNBR Protein, Human; IFRC Protein, Human
IFNAR1 Background Information
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Full Name
interferon (alpha, beta and omega) receptor 1
References
- Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
- Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
- Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
Human IFNAR1 Proteins
- IFNAR1 Protein, Human, Recombinant (hFc Tag)13222-H02H
- IFNAR1 Protein, Human, Recombinant (His Tag), HPLC-verifiedHPLC-13222-H08H
Mouse IFNAR1 Proteins
- IFNAR1 Protein, Mouse, Recombinant (His Tag)50469-M08H
Rhesus IFNAR1 Proteins
- IFNAR1 Protein, Rhesus, Recombinant (hFc Tag)90113-C02H
- IFNAR1 Protein, Rhesus, Recombinant (His Tag)90113-C08H
- IFNAR1 Protein, Rhesus, Recombinant90113-CCCH
- A potent in vivo anti-tumor efficacy of novel recombinant type I interferonAuthorZhang, K;Yin, XF;Yang, YQ;Li, HL;Xu, YN;Chen, LY;Liu, XJ;Yuan, SJ;Fang, XL;Xiao, J;Wu, S;Xu, H;Chu, L;Katlinski, KV;Katlinskaya, YV;Guo, RB;Wei, GW;Wang, DC;Liu, X;Fuchs, SY;Year2016JournalClin. Cancer Res.ApplicationbindingFoldedExpand
- A potent in vivo anti-tumor efficacy of novel recombinant type I interferonAuthorZhang, K;Yin, XF;Yang, YQ;Li, HL;Xu, YN;Chen, LY;Liu, XJ;Yuan, SJ;Fang, XL;Xiao, J;Wu, S;Xu, H;Chu, L;Katlinski, KV;Katlinskaya, YV;Guo, RB;Wei, GW;Wang, DC;Liu, X;Fuchs, SY;Year2016JournalClin. Cancer Res.ApplicationbindingFoldedExpand
- Functional Comparison of IFN‐α Subtypes Reveals Potent HBV Suppression by a Concerted Action of IFN‐α and ‐γ SignalingAuthorChen, J;Li, Y;Lai, F;Wang, Y;Sutter, K;Dittmer, U;Ye, J;Zai, W;Liu, M;Shen, F;Wu, M;Hu, K;Li, B;Lu, M;Zhang, X;Zhang, J;Li, J;Chen, Q;Yuan, Z;Year2020JournalHepatologyFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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