Sino Biological/Hsp90 alpha Protein, Human, Recombinant/1/11445-HNCE
商品编号：
11445-HNCE
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Hsp90 alpha Protein, Human, Recombinant: Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human HSP90 isoform 2 (NP_005339.3) C-terminal segment, corresponding to amino acid sequence (Glu 535-Asp 732) was expressed and purified, with two additonal aa (Gly & Pro) at the N terminus.
Accession#
NP_005339.3
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Gly
Molecule Mass
The recombinant human HSP90 (aa 535-732) consisting of 200 amino acids and has a calculated molecular mass of 22.6 kDa. It migrates as an 24 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Hsp90 alpha Protein, Human, Recombinant: Images
Hsp90 alpha Protein, Human, Recombinant: Synonyms
EL52 Protein, Human; HSP86 Protein, Human; Hsp89 Protein, Human; HSP89A Protein, Human; Hsp90 Protein, Human; HSP90A Protein, Human; HSP90N Protein, Human; HSPC1 Protein, Human; HSPCA Protein, Human; HSPCAL1 Protein, Human; HSPCAL4 Protein, Human; HSPN Protein, Human; LAP-2 Protein, Human; LAP2 Protein, Human
Hsp90 alpha Background Information
Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with "client proteins", including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ability to influence signal transduction, chromatin remodeling and epigenetic regulation, development, and morphological evolution. HSP90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis at the N-terminus. Disruption of HSP90 leads to client protein degradation and often cell death. Under stressful conditions, HSP90 stabilizes its client proteins and protects the cell against cellular stressors such as in cancer cells. Especially, several oncoproteins act as HSP90 client proteins and tumor cells require higher HSP90 activity than normal cells to maintain their malignancy. For this reason, Hsp90 has emerged as a promising target for anti-cancer drug development.
Full Name
heat shock protein 90kDa alpha (cytosolic), class A member 1
Research Areas
- Cancer Drug Targets
Related Pathways
Actin Dynamics Signaling Pathway
AKT Signaling Pathway
IL17 signaling pathway
References
- Pearl LH, et al. (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J. 410(3): 439-53.
- Hahn JS. (2009) The Hsp90 chaperone machinery: from structure to drug development. BMB Rep. 42(10): 623-30.
- Holzbeierlein JM, et al. (2010) Hsp90: a drug target? Curr Oncol Rep. 12(2): 95-101.
- Trepel J, et al. (2010) Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 10(8): 537-49.
- Lipid droplet binding thalidomide analogs activate endoplasmic reticulum stress and suppress hepatocellular carcinoma in a chemically induced transgenic mouse modelAuthorNagy, LI;Molnár, E;Kanizsai, I;Madácsi, R;Ózsvári, B;Fehér, LZ;Fábián, G;Marton, A;Vizler, C;Ayaydin, F;Kitajka, K;Hackler, L;Mátés, L;Deák, F;Kiss, I;Puskás, LG;Year2013JournalLipids Health DisPubMed ID: 24268070FoldedExpand
- Pan-amyloid oligomer specific scFv antibody attenuates memory deficits and brain amyloid burden in mice with Alzheimer"s diseaseAuthorZhao, M;Wang, SW;Wang, YJ;Zhang, R;Li, YN;Su, YJ;Zhou, WW;Yu, XL;Liu, RT;Year2014JournalCurr Alzheimer ResPubMed ID: 24156260FoldedExpand
- Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathwayAuthorHu, B;Zhang, Y;Jia, L;Wu, H;Fan, C;Sun, Y;Ye, C;Liao, M;Zhou, J;Year2015JournalAutophagyApplicationbindingPubMed ID: 25714412FoldedExpand
- Bioinformatics driven new immune target discovery in diseaseAuthorYang, C;Chen, P;Zhang, W;Du, H;Year2016JournalScand. J. Immunol.ApplicationELISAPubMed ID: 27226232FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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