Sino Biological/LIFR Protein, Human, Recombinant (His Tag)/1/10628-H08H
商品编号：
10628-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
LIFR Protein, Human, Recombinant (His Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its ability to bind human LIF-Fc (Cat:14890-H02H) in a functional ELISA.
Protein Construction
A DNA sequence encoding the extracellular domain of human LIFR (NP_001121143.1) (Met 1-Ser 833) with a C-terminal polyhistidine tag was expressed.
Accession#
NP_001121143.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Gln 45
Molecule Mass
The secreted recombinant human LIFR comprises 800 amino acids with a predicted molecular mass of 91 kDa. As a result of glycosylation, rhLIFR migrates as an approximately 125-135 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
LIFR Protein, Human, Recombinant (His Tag): Images
Measured by its ability to bind human LIF-Fc (Cat: 14890-H02H) in a functional ELISA.
LIFR Protein, Human, Recombinant (His Tag): Synonyms
CD118 Protein, Human; LIF-R Protein, Human; SJS2 Protein, Human; STWS Protein, Human; SWS Protein, Human
LIFR Background Information
LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world"s top five causes of cancer-related deaths.
Full Name
leukemia inhibitory factor receptor alpha
References
- Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
- Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
- Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
- Timmermann, A. et al.,2002, Eur. J. Biochem. 269 (11): 2716-2726.
- Lass, A. et al.,2002, Fertil. Steril. 76 (6): 1091-1096.
Human LIFR Proteins
- LIFR Protein, Human, Recombinant (His Tag), Biotinylated10628-H08H-B
- LIFR Protein, Human, Recombinant (ECD, hFc Tag)10628-H02H
Mouse LIFR Proteins
- LIFR Protein, Mouse, Recombinant (His Tag)50423-M08H
Rat LIFR Proteins
- LIFR Protein, Rat, Recombinant (His Tag)80322-R08H
- Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell ApoptosisAuthorYang, J;Qian, S;Cai, X;Lu, W;Hu, C;Sun, X;Yang, Y;Yu, Q;Gao, SP;Cao, P;Year2016JournalMol. Cancer Ther.PubMed ID: 26929249FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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