Sino Biological/RAGE Protein, Mouse, Recombinant (His Tag)/1/50489-M08H
商品编号：
50489-M08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
RAGE Protein, Mouse, Recombinant (His Tag): Product Information
Purity
> 96 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured by its ability to bind mouse HMGB1-Fc in functional ELISA.
Protein Construction
A DNA sequence encoding the extracellular domain of mouse AGER (NP_031451.2) extracellular domain (Met 1-Ala 342) was expressed, with a polyhistidine tag at the C-terminus.
Accession#
NP_031451.2
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Gln 24
Molecule Mass
The recombinant mouse AGER consists of 330 amino acids and has a predicted molecular mass of 35.3 kDa. In SDS-PAGE under reducing conditions, rm AGER migrates as an approximately 48 kDa band due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
RAGE Protein, Mouse, Recombinant (His Tag): Images
Measured by its ability to bind mouse HMGB1-Fc in functional ELISA.
RAGE Protein, Mouse, Recombinant (His Tag): Synonyms
RAGE Protein, Mouse
RAGE Background Information
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer"s disease, atherosclerosis and aging associated diseases.
Full Name
advanced glycosylation end product-specific receptor
References
- Zhou Z, et al. (2011) RAGE and its ligands in bone metabolism. Front Biosci (Schol Ed). 3: 768-76.
- Mosquera JA. (2010) Role of the receptor for advanced glycation end products (RAGE) in inflammation]. Invest Clin. 51(2): 257-68.
- D"Agati V, et al. (2010) RAGE and the pathogenesis of chronic kidney disease. Nat Rev Nephrol. 6(6): 352-60.
Human RAGE Proteins
- RAGE Protein, Human, Recombinant (His Tag)11629-H08H
- RAGE Protein, Human, Recombinant11629-HCCH
- RAGE Protein, Human, Recombinant (hFc Tag)11629-H02H
- RAGE Protein, Human, Recombinant (ECD, hFc Tag)11629-H02H1
- Disulfide HMGB1 derived from platelets coordinates venous thrombosis in miceAuthorStark, K;Philippi, V;Stockhausen, S;Busse, J;Antonelli, A;Miller, M;Schubert, I;Hoseinpour, P;Chandraratne, S;von Brühl, ML;Gaertner, F;Lorenz, M;Agresti, A;Coletti, R;Antoine, DJ;Heermann, R;Jung, K;Reese, S;Laitinen, I;Schwaiger, M;Walch, A;Sperandio, M;Nawroth, PP;Reinhardt, C;Jäckel, S;Bianchi, ME;Massberg, S;Year2016JournalBloodApplicationbindingPubMed ID: 27574188FoldedExpand
- The C-terminal tails of 4,4"-diphenylmethane-bis(methyl) carbamate are essential for binding to receptor for advanced glycation end products to attenuate advanced glycation end products-induced inflammation and apoptosis responses in human umbilical vein endothelial cellsAuthorFeng, L;Zhu, MM;Bu, WQ;Wang, CF;Zheng, ZG;Wang, RS;Jia, XB;Zhu, Q;Year2016JournalJ. Pharm. Pharmacol.ApplicationbindingFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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