Sino Biological/IL11RA蛋白，人，重组（His-Tag）/1/10252-H08H
商品编号：
10252-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL11RA Protein, Human, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the extracellular domain of human IL11Rα (NP_004503.1) (Met 1-Val 363) was expressed, with a fused polyhistidine tag at the C-terminus.
Accession#
NP_004503.1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ser 24
Molecule Mass
The recombinant human IL11Rαcomprises 351 amino acids and predicts a molecular mass of 38.6 kDa. As a result of glycosylation, rh IL11Rα migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL11RA Protein, Human, Recombinant (His Tag): Images
IL11RA Protein, Human, Recombinant (His Tag): Synonyms
CRSDA Protein, Human; hCG_2011440 Protein, Human; IL11RA Protein, Human; MGC2146 Protein, Human
IL11RA Background Information
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to the ciliary neurotrophic factor since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11, and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.
Full Name
interleukin 11 receptor subunit alpha
Related Pathways
AKT Signaling Pathway
Jak-Stat Signaling Pathway
Autophagy Pathway
References
- Van Leuven F, et al. (1996) Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Genomics. 31 (1): 65-70.
- Yoshizaki A, et al. (2006) Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Int J Oncol. 29 (4): 869-76.
- Karube K, et al. (2006) Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. Ann Oncol. 17 (1): 110-6.
Mouse IL11RA Proteins
- IL11RA Protein, Mouse, Recombinant (His Tag)50075-M08H
Canine IL11RA Proteins
- IL11RA Protein, Canine, Recombinant (His Tag)70078-D08H
- IL11RA Protein, Canine, Recombinant70078-DCCH
- IL11RA Protein, Canine, Recombinant (hFc Tag)70078-D02H
- High-affinity interaction between interleukin-11 and S100P proteinAuthorKazakov, AS;Sokolov, AS;Rastrygina, VA;Solovyev, VV;Ismailov, RG;Mikhailov, RV;Ulitin, AB;Yakovenko, AR;Mirzabekov, TA;Permyakov, EA;Permyakov, SE;Year2015JournalBiochem. Biophys. Res. Commun.Applicationbinding; expressionFoldedExpand
- Expression, Purification, and Characterization of Interleukin-11 OrthologuesAuthorSokolov, AS;Kazakov, AS;Solovyev, VV;Ismailov, RG;Uversky, VN;Lapteva, YS;Mikhailov, RV;Pavlova, EV;Terletskaya, IO;Ermolina, LV;Permyakov, SE;Permyakov, EA;Year2016JournalMoleculesApplicationSPRFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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