Sino Biological/OX40蛋白，小鼠，重组（hFc标签）/1/50808-M02H
商品编号：
50808-M02H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OX40 Protein, Mouse, Recombinant (hFc Tag): Product Information
Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the extracellular domain of mouse TNFRSF4 (NP_035789.1) (Met 1-Pro 211) was fused with the Fc region of human IgG1 at the C-terminus.
Accession#
NP_035789.1
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Val 20
Molecule Mass
The recombinant mouse TNFRSF4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 433 amino acids and has a calculated molecular mass of 48.3 kDa. As a result of glycosylation, the apparent molecular mass of the monomer is approximately 60 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
OX40 Protein, Mouse, Recombinant (hFc Tag): Images
OX40 Protein, Mouse, Recombinant (hFc Tag): Synonyms
ACT35 Protein, Mouse; CD134 Protein, Mouse; Ly-70 Protein, Mouse; Ox40 Protein, Mouse; Txgp1 Protein, Mouse; TXGP1L Protein, Mouse
OX40 Background Information
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
- Cancer Immunotherapy
- Co-stimulatory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Proteins
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
tumor necrosis factor receptor superfamily, member 4
Research Areas
- Cancer Drug Targets
References
- Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
- Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
- Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
Human OX40 Proteins
- OX40 Protein, Human, Recombinant (His & hFc Tag)10481-H03H
- OX40 Protein, Human, Recombinant (ECD, His Tag)10481-H08H
- OX40 Protein, Human, Recombinant (His Tag), Biotinylated10481-H08H-B
- OX40 Protein, Human, Recombinant (hFc Tag)10481-H02H
Mouse OX40 Proteins
- OX40 Protein, Mouse, Recombinant50808-MCCH
- OX40 Protein, Mouse, Recombinant (rFc Tag)50808-M31H
Rat OX40 Proteins
- OX40 Protein, Rat, Recombinant (hFc Tag)84472-R02H
Rhesus OX40 Proteins
- OX40 Protein, Rhesus, Recombinant (His Tag)90846-C08H
- OX40 Protein, Rhesus, Recombinant (hFc Tag)90846-C02H
- Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor EliminationAuthorFromm, G;de Silva, S;Giffin, L;Xu, X;Rose, J;Schreiber, TH;Year2016JournalCancer Immunol ResApplicationELISAFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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