华生物/IL17蛋白，小鼠，重组/1/51065-MNAE
商品编号：
51065-MNAE
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL17 Protein, Mouse, Recombinant: Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
1. Measured by its binding ability in a functional ELISA. Immobilized mouse Il17A (Cat: 51065-MNAE) at 2 μg/mL (100 μl/well) can bind mouse IL17RA-His (Cat: 50328-M08H), The EC50 of mouse IL17RA-His (Cat:50328-M08H) is 12-45 ng/mL.2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.15-0.6 ng/mL.
Protein Construction
A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.
Accession#
Q62386
Expressed Host
E. coli
Species
Mouse
Predicted N Terminal
Met
Molecule Mass
The recombinant mouse IL17a consists of 138 amino acids and predicts a molecular mass of 15.5 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL17 Protein, Mouse, Recombinant: Images
Measured by its binding ability in a functional ELISA. Immobilized mouse Il17A (Cat: 51065-MNAE) at 2 μg/mL (100 μl/well) can bind mouse IL17RA-His (Cat: 50328-M08H), The EC50 of mouse IL17RA-His (Cat:50328-M08H) is 12-45 ng/mL.
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.15-0.6 ng/mL.
IL17 Protein, Mouse, Recombinant: Synonyms
Ctla-8 Protein, Mouse; Ctla8 Protein, Mouse; IL-17 Protein, Mouse; IL-17A Protein, Mouse; Il17 Protein, Mouse
IL17 Background Information
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interleukin 17A
Research Areas
- Neuroinflammation
Related Pathways
IL12 signaling pathway
IL17 signaling pathway
References
- Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
- Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
- Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
- Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
Human IL17 Proteins
- IL17 Protein, Human, Recombinant (His Tag)12047-H07B
- IL17 Protein, Human, Recombinant (His Tag)12047-H07Y
- IL17 Protein, Human, Recombinant12047-HNAE
- IL17 Protein, Human, Recombinant, Biotinylated12047-HNAE-B
- IL17 Protein, Human, Recombinant12047-HNAS
Mouse IL17 Proteins
- IL17 Protein, Mouse, Recombinant51065-MNAY
Cynomolgus IL17 Proteins
- IL17 Protein, Cynomolgus, Recombinant90880-CNAB
Rhesus IL17 Proteins
- IL17 Protein, Rhesus, Recombinant90306-KNAB
Canine IL17 Proteins
- IL17 Protein, Canine, Recombinant70102-DNAE
Rabbit IL17 Proteins
- IL17 Protein, Rabbit, Recombinant (His Tag)65006-T07B
- IL17 Protein, Rabbit, Recombinant65006-TNAE
Marmoset IL17 Proteins
- IL17 Protein, Marmoset, Recombinant90287-CNAE
- Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis modelAuthorDeng, Q;Chen, H;Liu, Y;Xiao, F;Guo, L;Liu, D;Cheng, X;Zhao, M;Wang, X;Xie, S;Qi, S;Yin, Z;Gao, J;Chen, X;Wang, J;Guo, N;Ma, Y;Shi, M;Year2016JournalBrain Behav. Immun.Applicationcell-basedPubMed ID: 27133786FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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