Sino Biological/Syndecan-1/CD138 Protein, Human, Recombinant (ECD, His Tag)/1/11429-H08H
商品编号：
11429-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Syndecan-1/CD138 Protein, Human, Recombinant (ECD, His Tag): Product Information
Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human SDC1 (NP_002988.3) extracellular domain (Met 1-Glu 251) was expressed, with a polyhistidine tag at the C-terminus.
Accession#
NP_002988.3
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Gln 18
Molecule Mass
The recombinant human SDC1 consists of 245 amino acids and predictes a molecular mass of 25.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh SDC1 is approximately 48-55 kDa due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Syndecan-1/CD138 Protein, Human, Recombinant (ECD, His Tag): Images
Syndecan-1/CD138 Protein, Human, Recombinant (ECD, His Tag): Synonyms
CD138 Protein, Human; SDC Protein, Human; SYND1 Protein, Human; syndecan Protein, Human; Syndecan-1 Protein, Human
Syndecan-1/CD138 Background Information
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
Full Name
syndecan 1
References
- Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
- Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
- Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
Mouse Syndecan-1/CD138 Proteins
- Syndecan-1/CD138 Protein, Mouse, Recombinant (His Tag)50641-M08H
Rat Syndecan-1/CD138 Proteins
- Syndecan-1/CD138 Protein, Rat, Recombinant (His Tag)80344-R08H
- Syndecan-1/CD138 Protein, Rat, Recombinant (hFc Tag)80344-R02H
Cynomolgus Syndecan-1/CD138 Proteins
- Syndecan-1/CD138 Protein, Cynomolgus, Recombinant (hFc Tag)90938-C02H
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- Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx DegradationAuthorRobich, M;Ryzhov, S;Kacer, D;Palmeri, M;Peterson, SM;Quinn, RD;Carter, D;Sheppard, F;Hayes, T;Sawyer, DB;Rappold, J;Prudovsky, I;Kramer, RS;Year2020JournalJ. Surg. Res.Applicationmice injectionPubMed ID: 32199337FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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