Sino Biological/CD59 Protein, Human, Recombinant (His Tag)/1/12474-H08H
商品编号：
12474-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD59 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mature form of human CD59 (P13987-1) (Met 1-Glu 101) without the pro peptide was fused with a polyhistidine tag at the C-terminus.
Accession#
P13987-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Leu 26
Molecule Mass
The recombinant human CD59 consists of 87 amino acids and has a predicted molecular mass of 10.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD59 is approximately 13-19 kDa due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD59 Protein, Human, Recombinant (His Tag): Images
CD59 Protein, Human, Recombinant (His Tag): Synonyms
16.3A5 Protein, Human; 1F5 Protein, Human; EJ16 Protein, Human; EJ30 Protein, Human; EL32 Protein, Human; FLJ38134 Protein, Human; FLJ92039 Protein, Human; G344 Protein, Human; HRF-20 Protein, Human; HRF20 Protein, Human; MAC-IP Protein, Human; MACIF Protein, Human; MEM43 Protein, Human; MGC2354 Protein, Human; MIC11 Protein, Human; MIN1 Protein, Human; MIN2 Protein, Human; MIN3 Protein, Human; MIRL Protein, Human; MSK21 Protein, Human; p18-20 Protein, Human
CD59 Background Information
CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
Full Name
CD59 molecule
Related Pathways
Complement Activation Pathways
References
- Fletcher CM. et al., 1994, Structure. 2: 185-99.
- Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
- Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
- Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
- Picariello G. et al., 2008, Proteomics 8: 3833-47.
- Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
Rat CD59 Proteins
- CD59 Protein, Rat, Recombinant (hFc Tag)80299-R02H
- CD59 Protein, Rat, Recombinant (His Tag)80299-R08H
Cynomolgus CD59 Proteins
- CD59 Protein, Cynomolgus, Recombinant (His Tag)90188-C08H
- Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: Immune targets in demyelinating neuropathies?AuthorMiyaji, K;Paul, F;Shahrizaila, N;Umapathi, T;Yuki, N;Year2014JournalJ. Neuroimmunol.PubMed ID: 25156074FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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