Sino Biological/ICOS ligand Protein, Human, Recombinant (hFc Tag)/1/11559-H02H
商品编号：
11559-H02H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ICOS ligand Protein, Human, Recombinant (hFc Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human ICOSLG (O75144-1) (Met1-Ser258) was expressed with the Fc region of human IgG1 at the C-terminus.
Accession#
O75144-1
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Asp 19
Molecule Mass
The recombinant human ICOSLG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 66-76 and 33 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
ICOS ligand Protein, Human, Recombinant (hFc Tag): Images
ICOS ligand Protein, Human, Recombinant (hFc Tag): Synonyms
B7-h2 Protein, Human; B7H2 Protein, Human; B7RP-1 Protein, Human; B7RP1 Protein, Human; CD275 Protein, Human; GL50 Protein, Human; ICOS ligand Protein, Human; ICOS-L Protein, Human; ICOSL Protein, Human; ICOSLG Protein, Human; LICOS Protein, Human
ICOS ligand Background Information
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
- Cancer Immunotherapy
- Co-stimulatory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
inducible T-cell co-stimulator ligand
Research Areas
- Cancer Drug Targets
References
- Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
- Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
- Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
Human ICOS ligand Proteins
- ICOS ligand Protein, Human, Recombinant (ECD, His Tag)11559-H08H
- ICOS ligand Protein, Human, Recombinant (His Tag), Biotinylated11559-H08H-B
Mouse ICOS ligand Proteins
- ICOS ligand Protein, Mouse, Recombinant (His & hFc Tag)50190-M03H
- ICOS ligand Protein, Mouse, Recombinant (His Tag)50190-M08H
Rat ICOS ligand Proteins
- ICOS ligand Protein, Rat, Recombinant (His Tag)81346-R08H
- ICOS ligand Protein, Rat, Recombinant (hFc Tag)81346-R02H
Cynomolgus ICOS ligand Proteins
- ICOS ligand Protein, Cynomolgus, Recombinant (ECD, His Tag)90800-C08H
- ICOS ligand Protein, Cynomolgus, Recombinant (hFc Tag)90800-C02H
- Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte‐derived Dendritic CellsAuthorC Cairo, N Surendran, KM Harris…Year2014JournalImmunologyApplicationcell-basedPubMed ID: 25227493FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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