Sino Biological/TrkA Protein, Human, Recombinant (His Tag)/1/11073-H08H
商品编号：
11073-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TrkA Protein, Human, Recombinant (His Tag): Product Information
Purity
> 98 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human NTRK1 (NP_002520.2) extracellular domain (Met 1-Pro 382) was expressed with a C-terminal polyhistidine tag.
Accession#
NP_002520.2
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ala 33
Molecule Mass
The recombinant human NTRK1 consists of 361 amino acids and has a predicted molecular mass of 39.5 kDa. As a result of glycosylation, it migrates as an approximately 60-65 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TrkA Protein, Human, Recombinant (His Tag): Images
TrkA Protein, Human, Recombinant (His Tag): Synonyms
MTC Protein, Human; p140-TrkA Protein, Human; TRK Protein, Human; Trk-A Protein, Human; TRK1 Protein, Human; TRKA Protein, Human
TrkA Background Information
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as the establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
neurotrophic tyrosine kinase, receptor, type 1
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
- Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
- Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
Human TrkA Proteins
- TrkA Protein, Human, Recombinant (aa 194-413, His Tag)11073-H07H2
- TrkA Protein, Human, Recombinant (His & hFc Tag)11073-H03H
- TrkA Protein, Human, Recombinant (aa 285-413, His Tag)11073-H07E1
Mouse TrkA Proteins
- TrkA Protein, Mouse, Recombinant (hFc Tag)51103-M02H
- TrkA Protein, Mouse, Recombinant (His Tag)51103-M08H
Rat TrkA Proteins
- TrkA Protein, Rat, Recombinant (His Tag)80404-R08H
- TrkA Protein, Rat, Recombinant (hFc Tag)80404-R02H
Canine TrkA Proteins
- TrkA Protein, Canine, Recombinant (hFc Tag)70101-D01H
- TrkA Protein, Canine, Recombinant (His Tag)70101-D07H
Rabbit TrkA Proteins
- TrkA Protein, Rabbit, Recombinant (His Tag)65159-T08H
- A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activityAuthorSA Olwill, C Joffroy, H Gille, E Vigna…Year2013JournalMolecular Cancer TherapeuticsPubMed ID: 24002935FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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