Sino Biological/CD8 alpha Protein, Mouse, Recombinant (His Tag)/1/50389-M08H
商品编号：
50389-M08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD8 alpha Protein, Mouse, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
1. Measured by its ability to bind biotinylated recombinant human B2M in a functional ELISA.2. Measured by its ability to bind biotinylated recombinant human FCGRT+B2M in a functional ELISA.3. Measured by its ability to bind biotinylated recombinant human LCK in a functional ELISA.
Protein Construction
A DNA sequence encoding the extracellular domain of mouse CD8a (NP_001074579.1) (Met 1-Tyr 196) was expressed, with a C-terminal polyhistidine tag.
Accession#
NP_001074579.1
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Lys 28
Molecule Mass
The secreted recombinant mouse CD8a consists of 180 amino acids and has a calculated molecular mass of 20.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa protein in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD8 alpha Protein, Mouse, Recombinant (His Tag): Images
CD8 alpha Protein, Mouse, Recombinant (His Tag): Synonyms
BB154331 Protein, Mouse; Ly-2 Protein, Mouse; Ly-35 Protein, Mouse; Ly-B Protein, Mouse; Lyt-2 Protein, Mouse
CD8 alpha Background Information
T-cell surface glycoprotein CD8alpha chain, also known as CD8a, is a single-pass type I membrane protein. TheCD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer(NK) cells and has been implicated in the recognition of monomorphicdeterminants on major histocompatibility complex (MHC) Class I antigens, and insignal transduction during the course of T-cell activation. Both human androdent CD8 antigens are comprised of two distinct polypeptide chains, alpha andbeta. The Ig domains of CD8 alpha are involved in controlling the ability ofCD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alphareduced the ability of the protein to fold properly and, therefore, to beexpressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8deficiency is a novel autosomal recessive immunologic defect characterized byabsence of CD8+ cells, leading to recurrent bacterial infections.
Full Name
CD8a molecule
References
- ReferencesDevine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
Human CD8 alpha Proteins
- CD8 alpha Protein, Human, Recombinant (His Tag)10980-H08H
- CD8 alpha Protein, Human, Recombinant (His Tag), Biotinylated10980-H08H-B
- CD8 alpha Protein, Human, Recombinant (ECD, hFc Tag)10980-H02H
Mouse CD8 alpha Proteins
- CD8 alpha Protein, Mouse, Recombinant (hFc Tag)50389-M02H
- CD8 alpha Protein, Mouse, Recombinant (His Tag), Biotinylated50389-M08H-B
Rat CD8 alpha Proteins
- CD8 alpha Protein, Rat, Recombinant (hFc Tag)80285-R02H
Cynomolgus CD8 alpha Proteins
- CD8 alpha Protein, Cynomolgus, Recombinant (ECD, hFc Tag)90888-C02H
Ferret CD8 alpha Proteins
- CD8 alpha Protein, Ferret, Recombinant (His Tag)60001-F08H
- Functional ligands to target moleculesAuthorGW JacksonYear2013JournalUS Patent App. 13/748,566FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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