Sino Biological/Thrombopoietin Protein, Human, Recombinant (His Tag)/1/10381-H08C
商品编号：
10381-H08C
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Thrombopoietin Protein, Human, Recombinant (His Tag): Product Information
Purity
> 85 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 50-200 ng/ml.
Protein Construction
A DNA sequence encoding the human THPO (NP_000451.1) precursor (Met 1-Gly 353) was fused with a polyhistidine tag at the C-terminus.
Accession#
NP_000451.1
Expressed Host
CHO Cells
Species
Human
Predicted N Terminal
Ser 22
Molecule Mass
The recombinant human THPO consists of 343 amino acids with the predicted molecular mass of 36.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTHPO is approximately 60-80 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Thrombopoietin Protein, Human, Recombinant (His Tag): Images
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 50-200 ng/ml.
Thrombopoietin Protein, Human, Recombinant (His Tag): Synonyms
MGDF Protein, Human; MKCSF Protein, Human; ML Protein, Human; MPLLG Protein, Human; THCYT1 Protein, Human; TPO Protein, Human
Thrombopoietin Background Information
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.
Full Name
thrombopoietin
Research Areas
- Serine Proteases and Regulators
References
- Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
- Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?
Human Thrombopoietin Proteins
- Thrombopoietin Protein, Human, Recombinant (His Tag), Biotinylated10381-H07H-B
- Thrombopoietin Protein, Human, Recombinant (hFc Tag)10381-H02H
- Thrombopoietin Protein, Human, Recombinant (His Tag)10381-H07H
- Thrombopoietin Protein, Human, Recombinant (His Tag)10381-H08H1
- Thrombopoietin Protein, Human, Recombinant (His Tag)10381-H08H
Mouse Thrombopoietin Proteins
- Thrombopoietin Protein, Mouse, Recombinant (His Tag)50146-M08H
Cynomolgus Thrombopoietin Proteins
- Thrombopoietin Protein, Cynomolgus, Recombinant (His Tag)90004-C08H
- Selecting agonists from single cells infected with combinatorial antibody librariesAuthorH Zhang, K Yea, J Xie, D Ruiz, IA Wilson, RA LernerYear2013JournalChemistry & biologyPubMed ID: 23706638FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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