Sino Biological/EPCR Protein, Human, Recombinant (His Tag)/1/13320-H08H
商品编号：
13320-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
EPCR Protein, Human, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the extracellular domain of human PROCR (Q9UNN8) (Met 1-Thr 209), was fused with a polyhistidine tag at the C-terminus.
Accession#
Q9UNN8
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ser 18
Molecule Mass
The secreted recombinant human PROCR consists of 203 amino acids and has a predicted molecular mass of 23.4 kDa. The apparent molecular mass of rhPROCR is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EPCR Protein, Human, Recombinant (His Tag): Images
EPCR Protein, Human, Recombinant (His Tag): Synonyms
CCCA Protein, Human; CCD41 Protein, Human; EPCR Protein, Human
EPCR Background Information
Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC"s anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
Full Name
protein C receptor, endothelial
Research Areas
- Serine Proteases and Regulators
References
- Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
- Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
- Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.
Human EPCR Proteins
- EPCR Protein, Human, Recombinant (hFc Tag)13320-H02H
Mouse EPCR Proteins
- EPCR Protein, Mouse, Recombinant (His Tag)50874-M08H
- EPCR Protein, Mouse, Recombinant (hFc Tag)50874-M02H
Rat EPCR Proteins
- EPCR Protein, Rat, Recombinant (His Tag)80362-R08H
Cynomolgus EPCR Proteins
- EPCR Protein, Cynomolgus, Recombinant (hFc Tag)90229-C02H
- EPCR Protein, Cynomolgus, Recombinant (His Tag)90229-C08H
- Severe malaria is associated with parasite binding to endothelial protein C receptorAuthorL Turner, T Lavstsen, SS Berger, CW Wang…Year2013JournalNatureApplicationELISAFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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