Sino Biological/MICB蛋白，人，重组（His-Tag）/1/10759-H08H
商品编号：
10759-H08H
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MICB Protein, Human, Recombinant (His Tag): Product Information
Purity
> 98 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Immobilized human MICB-His (Cat:10759-H08H) at 10 μg/ml (100 μl/well) can bind S4-Fc3L3-NKG2D (Cat:10575-H01S), The EC50 of S4-Fc3L3-NKG2D (Cat:10575-H01S) is 0.52-1.2 μg/ml.
Protein Construction
A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was expressed with a C-terminal polyhistidine tag.
Accession#
NP_005922.2
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Ala 23
Molecule Mass
The recombinant human MICB consists of 287 amino acids and has a predicted molecular mass of 33 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh MICB is approximately 45-50 kDa due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
MICB Protein, Human, Recombinant (His Tag): Images
Immobilized human MICB-His (Cat: 10759-H08H) at 10 μg/ml (100 μl/well) can bind S4-Fc3L3-NKG2D (Cat: 10575-H01S), The EC50 of S4-Fc3L3-NKG2D (Cat: 10575-H01S) is 0.52-1.2 μg/ml.
MICB Protein, Human, Recombinant (His Tag): Synonyms
PERB11.2 Protein, Human
MICB Background Information
MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without the capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B is minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
Full Name
MHC class I polypeptide-related sequence B
References
- Bauer, S. et al., 1999, Science. 285:727-729.
- Braud, V.M. et al., 1999, Curr. Opin. Immunol.11: 100-108.
- Groh, V. et al., 2001, Nature Immunol. 2: 255-260.
- Stephens, H., 2001, Trends Immunol. 22: 378-385.
- Borrego, F. et al., 2002, Mol. Immunol.38: 637–660.
- Groh, V. et al., 2002, Nature. 419:734-738.
Human MICB Proteins
- MICB Protein, Human, Recombinant (His & hFc Tag)10759-H03H
- Mic-binding antibodies and methods of use thereofAuthorJD WuYear2012JournalUS 20120315287 A1FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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