Sino Biological/Recombinant Anti-c-MET Antibody (APC), Rabbit Monoclonal/1/10692-R271-A
商品编号：
10692-R271-A
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Recombinant Anti-c-MET Antibody (APC), Rabbit Monoclonal General Information
Product name
Recombinant Anti-c-MET Antibody (APC), Rabbit Monoclonal
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human c-MET
Immunogen
Recombinant Human HGFR / c-MET protein (Catalog#10692-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human HGFR / c-MET (rh HGFR / c-MET; Catalog#10692-H08H; NP_000236.2; Met 1-Thr 932) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Source
Monoclonal Rabbit IgG Clone #271
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
APC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Recombinant Anti-c-MET Antibody (APC), Rabbit Monoclonal Images
-R271-FITC-PE-APC-HepG2.png)
Profile of anti-human C-Met (HGF R) reactivity on HepG2 cells analyzed by flow cytometry. The Clone R271 and R243 (Cat. No. 10692-R243-F) monoclonal antibodies are not cross-blocking.
Recombinant Anti-c-MET Antibody (APC), Rabbit Monoclonal: Synonyms
Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody
c-MET Background Information
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
MET proto-oncogene, receptor tyrosine kinase
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
- Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
- Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
- Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.
- Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapyAuthorMahameed, M;Boukeileh, S;Obiedat, A;Darawshi, O;Dipta, P;Rimon, A;McLennan, G;Fassler, R;Reichmann, D;Karni, R;Preisinger, C;Wilhelm, T;Huber, M;Tirosh, B;Year2020JournalNat CommunApplicationFACSPubMed ID: 32161259FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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