Sino Biological/Recombinant Anti-CD64 Antibody, Rabbit Monoclonal/1/50086-R001
商品编号：
50086-R001
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Recombinant Anti-CD64 Antibody, Rabbit Monoclonal General Information
Product name
Recombinant Anti-CD64 Antibody, Rabbit Monoclonal
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD64Has cross-reactivity in ELISA withHuman CD64 / FCGR1ANo cross-reactivity in ELISA withMouse CD16-2 /FCGR4Mouse FCGR2B / CD32Mouse FCGR3 / CD16Human CD16a / FCGR3AHuman CD16b / FCGR3BHuman CD32a / FCGR2AHuman CD32b / FCGR2B
Immunogen
Recombinant Mouse FCGR1 protein (Catalog#50086-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FCGR1 extracellular domain (rM FCGR1; Catalog#50086-M08H; NP_034316.1; Met 1-Pro 297).
Source
Monoclonal Rabbit IgG Clone #1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Recombinant Anti-CD64 Antibody, Rabbit Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:5000-1:10000 |
| IHC-P | 1:100-1:500 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Recombinant Anti-CD64 Antibody, Rabbit Monoclonal Images
Immunochemical staining of mouse FCGR1 in mouse spleen with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Immunochemical staining of mouse FCGR1 in mouse liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to Kupffer cell.
Immunochemical staining of mouse FCGR1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to microglia.
Recombinant Anti-CD64 Antibody, Rabbit Monoclonal: Synonyms
Anti-AI323638 Antibody; Anti-AV092959 Antibody; Anti-CD64 Antibody; Anti-FcgammaRI Antibody; Anti-IGGHAFC Antibody
CD64 Background Information
High affinity immunoglobulingamma Fc receptor I, also known as FCGR1 and CD64, is an integralmembraneglycoprotein and a member of the immunoglobulin superfamily. CD64is a high affinity receptor for the Fc region of IgG gamma and functions inboth innate and adaptive immune responses. Receptors that recognize the Fcportion of IgG function in the regulation of immune response and are dividedinto three classes designated CD64, CD32, and CD16. CD64 is structurallycomposed of asignal peptidethat allows its transport to the surfaceof a cell, threeextracellularimmunoglobulin domainsof theC2-type that it uses to bind antibody, a hydrophobictransmembrane domain,and a short cytoplasmic tail. CD64 isconstitutivelyfound on onlymacrophages and monocytes, but treatment of polymorphonuclearleukocyteswith cytokines likeIFNγandG-CSFcaninduce CD64 expression on these cells. The inactivation of the mouse CD64resulted in a wide range of defects in antibody Fc-dependent functions. MouseCD64 is an early participant in Fc-dependent cell activation and in thedevelopment of immune responses.
Full Name
Fc receptor, IgG, high affinity I
Research Areas
- Fc Receptors
References
- Allen J.M., et al.,(1988), Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI). Nucleic Acids Res. 16:11824-11824.
- Allen J.M., et al., (1989), Isolation and expression of functional high-affinity Fc receptor complementary DNAs.Science 243:378-381.
- Porges A.J., et al.,(1992), Novel Fc gamma receptor I family gene products in human mononuclear cells.J. Clin. Invest. 90:2102-2109.
- Cartilage-binding antibodies induce pain through immune complex-mediated activation of neuronsAuthorBersellini Farinotti, A;Wigerblad, G;Nascimento, D;Bas, DB;Morado Urbina, C;Nandakumar, KS;Sandor, K;Xu, B;Abdelmoaty, S;Hunt, MA;Ängeby Möller, K;Baharpoor, A;Sinclair, J;Jardemark, K;Lanner, JT;Khmaladze, I;Borm, LE;Zhang, L;Wermeling, F;Cragg, MS;Lengqvist, J;Chabot-Doré, AJ;Diatchenko, L;Belfer, I;Collin, M;Kultima, K;Heyman, B;Jimenez-Andrade, JM;Codeluppi, S;Holmdahl, R;Svensson, CI;Year2019JournalJ. Exp. Med.ApplicationIHCPubMed ID: 31196979FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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