Sino Biological/Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit MAb/1/10202-R038
商品编号：
10202-R038
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit MAb General Information
Product name
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit MAb
Validated applications
WB,ELISA
Application notes
IHC, FCM, IF, IP et al. applications haven"t been validated.(Antibody"s applications haven"t been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
CMV CMV Glycoprotein B
Immunogen
Recombinant Human CMV gB / Glycoprotein B protein (Catalog#10202-V08H1)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CMV gB (Catalog#10202-V08H1; AAA45920.1) extracellular domain (Met 1-Lys 700) linked with the cytoplasmic domain (Arg 777-Val 907).
Source
Monoclonal Rabbit IgG Clone #38
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit MAb Validated Applications
| Application | Dilution |
|---|---|
| WB | his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect Human CMV gB in WB. Using a DAB detection system, the detection limit for Human CMV gB is approximately 0.125 ng/lane under non-reducing conditions and 100 ng/lane under reducing conditions. |
| ELISA | 1:5000-1:10000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
CMV Glycoprotein B Background Information
Cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 97-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.
References
- Lopper M,et al. (2002). Disulfide bond configuration of human cytomegalovirus glycoprotein B. J Virol. 76(12): 6073-82.
- Isaacson MK, et al. (2009) Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress. J Virol. 83(8): 3891-903.
- Exploring the N-Glycosylation Profile of Glycoprotein B from Human Cytomegalovirus Expressed in CHO and Nicotiana tabacum BY-2 CellsAuthorSmargiasso, N;Nader, J;Rioux, S;Mazzucchelli, G;Boutry, M;De Pauw, E;Chaumont, F;Navarre, C;Year2019JournalInt J Mol SciApplicationWBPubMed ID: 31370181FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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